MODEL GENETIC CIRCUITS ENCODING AUTOREGULATORY TRANSCRIPTION FACTORS
MODEL GENETIC CIRCUITS ENCODING AUTOREGULATORY TRANSCRIPTION FACTORS
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DOI：
10.1006/jtbi.1995.0014
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发表时间：
1995-01-21
影响因子：
2
通讯作者：
KELLER, AD
中科院分区：
文献类型：
--
作者：
KELLER, AD
多个稳态水平的自我调节转录因子能够指定细胞或生物体的替代遗传表型。在稳定状态之间切换可能会导致长期的表型变化。在这篇文章中，提出了六个模型遗传电路，每个模型编码一组自我调节转录因子。建立并求解了每个遗传电路的稳态速率方程，以确定存在多个稳态的条件。遗传回路的每一种稳定状态都构成了由单一基因产生的另一种可遗传表型。
Multiple steady-state levels of autoregulatory transcription factors are capable of specifying alternative heritable phenotypes of a cell or an organism. Switching among steady states can result in long-term phenotypic change. In this paper, six model genetic circuits are presented, each encoding a set of autoregulatory transcription factors. The steady-state rate equations for each genetic circuit are formulated and solved to determine conditions under which multiple steady states exist. Each steady state of the genetic circuit constitutes an alternative heritable phenotype resulting from a single genotype.