Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
复制标题
DOI：
10.2147/opth.s234568
复制
发表时间：
2020-01-01
影响因子：
2.2
通讯作者：
Dahab, Ahmed A.
中科院分区：
文献类型：
--
作者：
Eissa, Iman M.;Nassar, Ghada A.;Dahab, Ahmed A.
目的：评价角膜厚度和地形参数的系统性红斑狼疮（SLE）患者使用双Scheimpflug Imaging.Methods：这项观察性横断面对照研究包括30例SLE患者和30例年龄匹配的对照右眼。通过双Scheimpflug成像获得角膜测量值，包括前、后角膜曲率、中央、中周边角膜厚度（在5 mm区域测量）和周边角膜厚度测量（在7 mm区域测量）。计算SLE疾病活动指数（SLEDAI），并与角膜厚度测量结果进行相关性分析。SLE组的平均中央角膜厚度为530.4 ± 27.3微米（SD），对照组为547.5 ± 31.5微米（SD），p = 0.032。SLE患者的角膜周边（上部除外）显著厚于对照组（p.0.001）。鼻周边角膜厚度与疾病活动指数SLEDAI呈正相关（p=0.03）。结论：SLE患者的角膜周边厚度较对照组厚，上级象限除外。可能的角膜光敏性导致外周免疫复合物沉积以及平坦的角膜后表面在周边提出了这些结果的解释。
Purpose: To evaluate the corneal pachymetric and topographic parameters of systemic Lupus Erythematosus (SLE) patients using Dual Scheimpflug Imaging.Methods: This observational cross-sectional controlled study included the right eye of 30 SLE patients and 30 age-matched controls. Corneal measurements were acquired by dual Scheimpflug imaging including anterior and posterior corneal curvatures, central, midperipheral corneal thickness (measured at the 5 mm zone) and peripheral pachymetry (measured at the 7 mm zone). SLE disease activity index (SLEDAI) was calculated and correlated with corneal pachymetry.Results: SLE patients had significantly thicker corneal periphery than controls. Mean central corneal pachymetry was 530.4 +/- 27.3 microns (SD) in SLE and 547.5 +/- 31.5 microns (SD) in control group, p = 0.032. The corneal periphery - except superiorly - was significantly thicker in SLE patients than controls (p.0.001). Nasal peripheral corneal thickness positively correlated with disease activity index SLEDAI (p=0.03).Conclusion: SLE patients present with thicker corneal periphery than controls characteristically sparing the superior quadrant. Possible corneal photosensitivity leading to peripheral immune complex deposition as well as flatter posterior corneal surface at the periphery are proposed explanations for these findings.