Autonomic Regulation Therapy in Heart Failure.
Autonomic Regulation Therapy in Heart Failure.
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DOI：
10.1007/s11897-015-0263-7
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发表时间：
2015-08
影响因子：
--
通讯作者：
Ardell JL
中科院分区：
文献类型：
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作者：
Buckley U;Shivkumar K;Ardell JL
自主神经调节疗法（ART）是治疗继发于收缩功能障碍的充血性心力衰竭的一种新兴疗法。心脏神经元层级的调制可以通过脊髓、颈迷走神经、压力感受器或肾神经消融的生物电子调制来实现。本文就ART治疗收缩性心力衰竭的相关临床前和临床研究进行综述。从机械上理解这种基于设备的治疗在自主神经系统内刺激了什么以及系统如何对这种刺激做出反应对于优化刺激参数和有效ART的未来发展至关重要。
Autonomic Regulation Therapy (ART) is a rapidly emerging therapy in the management of congestive heart failure secondary to systolic dysfunction. Modulation of the cardiac neuronal hierarchy can be achieved with bioelectronics modulation of the spinal cord, cervical vagus, baroreceptor, or renal nerve ablation. This review will discuss relevant preclinical and clinical research in ART for systolic heart failure. Understanding mechanistically what is being stimulated within the autonomic nervous system by such device-based therapy and how the system reacts to such stimuli is essential for optimizing stimulation parameters and for the future development of effective ART.