THE EFFECTS OF PLASMA-LIPOPROTEINS ON INVITRO TUMOR-CELL KILLING AND INVIVO TUMOR PHOTOSENSITIZATION WITH BENZOPORPHYRIN DERIVATIVE
THE EFFECTS OF PLASMA-LIPOPROTEINS ON INVITRO TUMOR-CELL KILLING AND INVIVO TUMOR PHOTOSENSITIZATION WITH BENZOPORPHYRIN DERIVATIVE
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DOI：
10.1111/j.1751-1097.1991.tb02079.x
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发表时间：
1991-11-01
影响因子：
3.3
通讯作者：
LEVY, JG
中科院分区：
文献类型：
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作者：
ALLISON, BA;WATERFIELD, E;LEVY, JG
在M-1荷瘤小鼠中研究了脂蛋白关联对肿瘤细胞体外杀伤和苯并卟啉衍生物（BDP）体内肿瘤光敏作用的影响。在静脉给药3小时后进行的体内/体外细胞毒性试验中，苯并卟啉单酸环A与低或高密度脂蛋白的关联增加了肿瘤细胞的杀伤。在光敏剂注射后8小时，与未分离血浆中的BPD相比，只有低密度脂蛋白（LDL）混合物产生了显著（P小于或等于0.005）的肿瘤细胞杀伤增加。脂蛋白存在下的体内光敏效果与体内/体外细胞毒性相关。BPD与低或高密度脂蛋白的关联导致肿瘤再生延迟，在给药后3小时进行光照（125J/cm2）时，治愈率更高。当注射后8小时进行光照照射时，与在水溶液或未分离血浆中施用BPD相比，只有LDL-BPD混合物能增强肿瘤根除。
The influence of lipoprotein association on in vitro tumor cell killing and in vivo tumor photosensitization with benzoporphyrin derivative (BDP) has been investigated in M-1 tumor bearing mice. The association of benzoporphyrin mono acid ring A with either low or high density lipoprotein increased tumor cell killing in an in vivo/in vitro cytotoxicity assay performed 3 h post intravenous drug administration. Eight hours following photosensitizer injection only low density lipoprotein (LDL) mixtures produced significant (P less-than-or-equal-to 0.005) increases in tumor cell killing compared to BPD in unfractionated plasma. The efficacy of in vivo photosensitization in the presence of lipoproteins correlated with the in vivo/in vitro cytotoxicity. Association of BPD with low or high density lipoproteins resulted in delayed tumor regrowth and higher cure rates when light exposure (125J/cm2) was performed 3 h post drug administration. When light exposure was performed 8 h post-injection only LDL-BPD mixtures led to enhanced tumor eradication compared to BPD administered in aqueous solution or unfractionated plasma.