Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer.
Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer.
复制标题
肺癌中的上皮到间质转变和microRNA。
DOI：
10.3390/cancers9080101
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发表时间：
2017-08-03
期刊：
影响因子：
5.2
通讯作者：
Blons H
中科院分区：
文献类型：
--
作者：
Legras A;Pécuchet N;Imbeaud S;Pallier K;Didelot A;Roussel H;Gibault L;Fabre E;Le Pimpec-Barthes F;Laurent-Puig P;Blons H
尽管取得了重大进展，但非小细胞肺癌（NSCLC）仍然是发达国家癌症相关死亡的主要原因。转移和耐药是导致复发和死亡的主要因素。上皮细胞向间质细胞转化（EMT）是一个复杂的分子和细胞过程，涉及组织重塑，其作为许多癌症类型和肺癌中肿瘤进展、转移和耐药性的因素被广泛研究。在这里，我们重点描述了NSCLC中发生在癌症中的信号通路、转录因子表达或microRNA的变化如何促进EMT。了解EMT的生物学将有助于确定逆转过程和治疗策略。我们将看到这种复杂的机制与炎症，细胞流动性和干细胞特征有关，并且它是一个动态过程。中间表型和肿瘤异质性的存在可能在关于NSCLC中EMT标志物、EMT特征和临床后果的文献中存在争议。然而，鉴于EMT在转移和耐药性中的作用，EMT抑制剂的开发是对抗肿瘤进展和耐药性的有趣方法。本文综述了EMT参与癌症，重点是NSCLC和microRNA调控。
Despite major advances, non-small cell lung cancer (NSCLC) remains the major cause of cancer-related death in developed countries. Metastasis and drug resistance are the main factors contributing to relapse and death. Epithelial-to-mesenchymal transition (EMT) is a complex molecular and cellular process involved in tissue remodelling that was extensively studied as an actor of tumour progression, metastasis and drug resistance in many cancer types and in lung cancers. Here we described with an emphasis on NSCLC how the changes in signalling pathways, transcription factors expression or microRNAs that occur in cancer promote EMT. Understanding the biology of EMT will help to define reversing process and treatment strategies. We will see that this complex mechanism is related to inflammation, cell mobility and stem cell features and that it is a dynamic process. The existence of intermediate phenotypes and tumour heterogeneity may be debated in the literature concerning EMT markers, EMT signatures and clinical consequences in NSCLC. However, given the role of EMT in metastasis and in drug resistance the development of EMT inhibitors is an interesting approach to counteract tumour progression and drug resistance. This review describes EMT involvement in cancer with an emphasis on NSCLC and microRNA regulation.
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影响因子：
8.8
作者：
Bryant, J. L.;Britson, J.;Balko, J. M.;Willian, M.;Timmons, R.;Frolov, A.;Black, E. P.
通讯作者：
Black, E. P.
影响因子：
11.2
作者：
Ardiani A;Gameiro SR;Palena C;Hamilton DH;Kwilas A;King TH;Schlom J;Hodge JW
通讯作者：
Hodge JW
影响因子：
3.7
作者：
Barr MP;Gray SG;Hoffmann AC;Hilger RA;Thomale J;O'Flaherty JD;Fennell DA;Richard D;O'Leary JJ;O'Byrne KJ
通讯作者：
O'Byrne KJ
DOI：
10.1158/1541-7786.mcr-14-0363
发表时间：
2015-03
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Alam M;Ahmad R;Rajabi H;Kufe D
通讯作者：
Kufe D
影响因子：
50.3
作者：
Ansieau, Stephane;Bastid, Jeremy;Puisieux, Alain
通讯作者：
Puisieux, Alain