Quantitative analysis of adenosine A1 receptors in human brain using positron emission tomography and [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine
Quantitative analysis of adenosine A1 receptors in human brain using positron emission tomography and [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine
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DOI：
10.1016/j.nucmedbio.2004.06.005
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发表时间：
2004-11-01
影响因子：
3.1
通讯作者：
Ishiwata, K
中科院分区：
文献类型：
--
作者：
Kimura, Y;Ishii, K;Ishiwata, K
本文报道了用C-11-MPDX和正电子发射断层扫描对脑内腺苷A（1）受体（A1 R）的全定量分析。动力学描述使用一个两组织三室模型，估计的结合电位对应的估计Logan图。MPDX的结合潜力的图像在生理上是合理的。结论：MPDX适用于脑内A1 R的Logan图显示。(C)2004爱思唯尔公司All rights reserved.
Fully quantitative analysis of the adenosine A(1) receptor (A1R) in the brain with C-11-MPDX and positron emission tomography is reported. The kinetics is described using a two-tissue three-compartment model, and estimated binding potentials correspond well with the estimates made by Logan plot. The image of the binding potential of the MPDX is physiologically reasonable. We conclude that MPDX is applicable to the visualization of the A1Rs in the brain with Logan plot. (C) 2004 Elsevier Inc. All rights reserved.