Eight weeks of exercise training improves fitness measures in methamphetamine-dependent individuals in residential treatment.
Eight weeks of exercise training improves fitness measures in methamphetamine-dependent individuals in residential treatment.
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DOI：
10.1097/adm.0b013e318282475e
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发表时间：
2013-03
影响因子：
5.5
通讯作者：
Cooper CB
中科院分区：
文献类型：
--
作者：
Dolezal BA;Chudzynski J;Storer TW;Abrazado M;Penate J;Mooney L;Dickerson D;Rawson RA;Cooper CB
体育锻炼已被证明对各种医疗和行为状况有益。本研究评估了为期8周的耐力和阻力训练计划的可行性和有效性的健身措施在个人接受住宅治疗甲基苯丙胺（MA）的依赖。共有39名MA依赖者被随机分配到3天/周的运动训练（ET，n=15）或健康教育无训练（EA，n=14）超过8周。有氧运动能力（VO 2 max）通过间接量热法测量，身体成分通过皮褶厚度测量，肌肉力量通过1-重复最大值（1-RM）测量，并且对于腿部推举（LP）和胸部推举（CP），耐力为1-RM的85%。共有29人完成了研究，依从率为74%。基线特征（平均值±SD）在组间均衡：年龄31±7岁;身高=1.74±0.07 m;体重82.0±15.0 kg。ET组VO 2 max显著改善0.63±0.22 L/min（+21%），LP强度显著改善24.4±5.6 kg（+40%），CP强度显著改善20.6±5.7 kg（+49%）。ET组的LP和CP耐力分别增加了120%和96%，体重显著降低1.7±2.4 kg（−2%），体脂百分比降低2.8±1.3%（−15%），脂肪重量降低2.8±1.8 kg（−18%）。电针组与对照组比较，ET的变化有显著性差异（P<0.001）。从甲基苯丙胺依赖中恢复的个体在有氧运动表现、肌肉力量和耐力以及运动训练的身体组成方面表现出实质性的改善。这些发现证明了在这些参与者中进行运动训练干预的可行性，并且还显示出对运动刺激的良好反应性，从而导致可能增强药物依赖恢复的生理变化。
Physical exercise has been shown to benefit diverse medical and behavioral conditions. This study assesses the feasibility and efficacy of an 8-week endurance and resistance training program on fitness measures in individuals undergoing residential treatment for methamphetamine (MA) dependence. A total of 39 MA-dependent individuals were randomized to 3 days/week of exercise training (ET, n=15) or health education without training (EA, n=14) over 8 weeks. Aerobic performance (VO2max) was measured by indirect calorimetry, body composition by skinfolds, muscle strength by 1-repetition maximum (1-RM) and endurance at 85% of 1-RM for both leg press (LP) and chest press (CP). A total of 29 individuals completed the study for a 74% adherence rate. Baseline characteristics (mean±SD) were balanced between groups: age 31±7 years; height=1.74±0.07 m; weight 82.0±15.0 kg. The ET group significantly improved VO2max by 0.63±0.22 L/min (+21%), LP strength by 24.4±5.6 kg (+40%) and CP strength by 20.6±5.7 kg (+49%). The ET group increased LP and CP endurance by 120% and 96%, respectively and showed significant reductions in body weight of 1.7±2.4 kg (−2%), % body fat of 2.8±1.3% (−15%) and fat weight 2.8±1.8 kg (−18%). All changes were significant (P<0.001) for ET, and no changes were seen for the EA group. Individuals recovering from methamphetamine dependence showed substantial improvements in aerobic exercise performance, muscle strength and endurance, and body composition with exercise training. These findings demonstrate the feasibility of an exercise training intervention in these participants and also show excellent responsiveness to the exercise stimulus resulting in physiological changes that might enhance recovery from drug dependency.