Requirement for diverse, low-abundance peptides in positive selection of T cells
Requirement for diverse, low-abundance peptides in positive selection of T cells
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DOI：
10.1126/science.283.5398.67
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发表时间：
1999-01-01
期刊：
影响因子：
56.9
通讯作者：
Rudensky, AY
中科院分区：
文献类型：
--
作者：
Barton, GM;Rudensky, AY
Whether a single major histocompatibility complex (MHC)-bound peptide can drive the positive selection of large numbers of T cells has been-a controversial. issue. A diverse population of self peptides was shown to be essential for the in vivo development of CD4 T cells. Mice in which all but 5 percent of MHC class II molecules were bound by a single peptide had wild-type numbers of CD4 T cells. However, when the diversity within this 5 percent was lost, CD4 T cell development was impaired. Blocking the major peptide-MHC complex in thymus organ culture had no effect on T cell development; indicating that positive selection occurred on the diverse peptides present at low levels, This requirement for peptide diversity indicates that the interaction between self peptides and T cell receptors during positive selection is highly specific.
