Physical Activity and Male Colorectal Cancer Survival
Physical Activity and Male Colorectal Cancer Survival
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DOI：
10.1001/archinternmed.2009.412
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发表时间：
2009-12-14
影响因子：
--
通讯作者：
Fuchs, Charles S.
中科院分区：
文献类型：
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作者：
Meyerhardt, Jeffrey A.;Giovannucci, Edward L.;Fuchs, Charles S.
背景资料：虽然体力活动的人有较低的风险发展为结直肠癌，很少有研究探讨是否行使受益结直肠癌survivors.Methods：来自卫生专业人员随访研究，我们研究了结直肠癌的特异性和整体死亡率在一个队列的668名男子的历史阶段I至III期结直肠癌根据预先定义的体力活动类别诊断后。为了最大限度地减少隐匿性复发的偏见，我们排除了男性谁在6个月内死亡的诊断后体力活动assessment.Results：在一个队列的男性结直肠癌和诊断时没有明显的转移，50.4%行使至少18代谢当量任务（MET）每周小时。增加体力活动与结直肠癌特异性死亡率（趋势P = .002）和总死亡率（趋势P < .001）的改善显著相关。与每周从事3小时或更少MET体力活动的男性相比，每周从事超过27小时MET体力活动的男性结直肠癌特异性死亡率的校正风险比为0.47（95%置信区间，0.24-0.92）。无论年龄，疾病分期，体重指数，诊断年，肿瘤位置，和诊断前的体力activity.Conclusion：在一个大的队列的男性非转移性结直肠癌的历史，更多的体力活动与结直肠癌的风险较低，具体的和整体的死亡率。
Background: Although physically active individuals have a lower risk of developing colorectal cancer, few studies have examined whether exercise benefits colorectal cancer survivors.Methods: Derived from the Health Professionals Follow-up Study, we studied colorectal cancer-specific and overall mortality in a cohort of 668 men with a history of stage I to stage III colorectal cancer according to pre-defined physical activity categories after diagnosis. To minimize bias by occult recurrences, we excluded men who died within 6 months of their post diagnosis physical activity assessment.Results: In a cohort of men with colorectal cancer and no apparent metastases at diagnosis, 50.4% exercised at least 18 metabolic equivalent task (MET) hours per week. Increased physical activity was significantly associated with improved colorectal cancer-specific mortality (P = .002 for trend) and overall mortality (P < .001 for trend). Men who engaged in more than 27 MET hours per week of physical activity had an adjusted hazard ratio for colorectal cancer-specific mortality of 0.47 (95% confidence interval, 0.24-0.92) compared with men who engaged in 3 or less MET hours per week of physical activity. The apparent benefit of physical activity was seen regardless of age, disease stage, body mass index, diagnosis year, tumor location, and pre-diagnosis physical activity.Conclusion: In a large cohort of men with a history of nonmetastatic colorectal cancer, more physical activity was associated with a lower risk of colorectal cancer-specific and overall mortality.