Embolization with radiopaque microbeads of polyacrylonitrile hydrogel:: Evaluation in swine
Embolization with radiopaque microbeads of polyacrylonitrile hydrogel:: Evaluation in swine
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DOI：
10.1148/radiology.214.1.r00ja40113
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发表时间：
2000-01-01
期刊：
影响因子：
19.7
通讯作者：
Chow, K
中科院分区：
文献类型：
--
作者：
Gobin, YP;Viñuela, F;Chow, K
目得：进行在体外和体内的研究，不透射线的聚丙烯腈（PAN）水凝胶微珠，以评估其特性作为栓塞material.MATERIALS和METHODS：PAN微珠进行了分析，在不同浓度的造影剂和生理盐水溶液中的溶胀，并通过各种微导管注入体外。在三只死亡的猪中，用PAN微珠栓塞各种器官。在8只存活的猪中，用PAN微珠或聚乙烯醇颗粒栓塞奇异网。结果：微球呈黑色，形状规则，表面光滑，在1个月和6个月时进行组织病理学检查。它们在注射器中很容易看到，并且易于通过微导管注射。当潮湿时，它们的直径增加了40%。微珠具有足够的不透射线性，在所有血管区域中可见。血管闭塞不是永久性的，即使栓塞充分，在3个月时也检测到一些血运重建。微珠是完整的，并且在6个月时仍然不透射线。组织学检查表明变量炎症反应和异物巨细胞反应，没有血管坏死或hemorrhages.CONCLUSION：因为PAN微珠是生物相容性，不透射线，易于处理栓塞过程中，他们有潜力作为一种治疗栓塞剂。
PURPOSE: To perform in vitro and in vivo studies of radiopaque microbeads of polyacrylonitrile (PAN) hydrogel to evaluate their characteristics as embolic material.MATERIALS AND METHODS: PAN microbeads were analyzed in vitro for swelling in different concentrations of contrast material and saline solution and injected through various microcatheters. In three nonsurvival swine, various organs were embolized with PAN microbeads. In eight survival swine, the rete mirabile was embolized with PAN microbeads or polyvinyl alcohol particles. Follow-up angiograms were obtained regularly, and histopathologic analysis was performed at 1 and 6 months.RESULTS: The microbeads were black with a regular shape and smooth surface. They were easily visible in the syringe and easy to inject through the microcatheters. When wet, their diameters increased by 40%. The microbeads were sufficiently radiopaque to be visible in all vascular territories. Vascular occlusion was not permanent, and even when embolization was adequate, some revascularization was detected at 3 months. The microbeads were intact and still radiopaque at 6 months. Histopathologic examination demonstrated variable inflammatory reactions and foreign-body giant cell reaction and no angionecrosis or hemorrhage.CONCLUSION: Because PAN microbeads are biocompatible, radiopaque, and easy to handle during embolization procedures, they have potential as a therapeutic embolic agent.