Clinically significant prostate cancer local recurrence after radiation therapy occurs at the site of primary tumor: magnetic resonance imaging and step-section pathology evidence
Clinically significant prostate cancer local recurrence after radiation therapy occurs at the site of primary tumor: magnetic resonance imaging and step-section pathology evidence
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DOI：
10.1016/j.ijrobp.2007.03.065
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发表时间：
2007-09-01
影响因子：
7
通讯作者：
Zelefsky, Michael J.
中科院分区：
文献类型：
--
作者：
Pucar, Darko;Hricak, Hedvig;Zelefsky, Michael J.
目的：通过回顾性比较放射治疗前和放射治疗后的磁共振成像（MRI）肿瘤位置，并以挽救性根治性切除术（SRP）后的阶梯切片病理作为参考标准，确定前列腺癌放射治疗（RT）后是否在原发肿瘤部位发生局部复发。方法和材料：9例局限性前列腺癌患者接受调强放疗（69-86.4戈伊）治疗，并接受放疗前和放疗后前列腺MRI、活检证实的局部复发和SRP。RT前和RT后MRI上病变的位置和体积与阶梯切片病理结果相关。结果：所有9个显著的肿瘤病灶（每例患者1个;体积范围0.22-8.63 cm（3））在RT前和RT后MRI上均被检测到，并且在RT前和RT后MRI上以及阶梯切片病理学上显示出惊人相似的外观。两个临床上不显著的肿瘤病灶（
Purpose: To determine whether prostate cancer local recurrence after radiation therapy (RT) occurs at the site of primary tumor by retrospectively comparing the tumor location on pre-RT and post-RT magnetic resonance imaging (MRI) and using step-section pathology after salvage radical prostatectomy (SRP) as the reference standard.Methods and Materials: Nine patients with localized prostate cancer were treated with intensity modulated RT (69-86.4 Gy), and had pre-RT and post-RT prostate MRI, biopsy-proven local recurrence, and SRP. The location and volume of lesions on pre-RT and post-RT MRI were correlated with step-section pathology findings. Tumor foci >0.2 cm(3) and/or resulting in extraprostatic disease on pathology were considered clinically significant.Results: All nine significant tumor foci (one in each patient; volume range, 0.22-8.63 cm(3)) were detected both on pre-RT and post-RT MRI and displayed strikingly similar appearances on pre-RT and post-RT MRI and step-section pathology. Two clinically insignificant tumor foci (