EVIDENCE FOR A VESICULAR TRANSPORT MECHANISM IN HEPATOCYTES FOR BILIARY-SECRETION OF IMMUNOGLOBULIN-A
EVIDENCE FOR A VESICULAR TRANSPORT MECHANISM IN HEPATOCYTES FOR BILIARY-SECRETION OF IMMUNOGLOBULIN-A
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DOI：
10.1126/science.7375938
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
HRADEK, GT
中科院分区：
文献类型：
--
作者：
RENSTON, RH;JONES, AL;HRADEK, GT
定量电子显微镜放射自显影和二氨基联苯胺细胞化学提供了证据，碘-125标记的免疫球蛋白A从血浆到胆汁的肝细胞在体内的摄取和囊泡运输机制。这些数据证实了存在将免疫球蛋白A分泌到肠中的肝胆途径，并且与肝实质细胞内胆汁蛋白的囊泡转运机制一致。
Quantitative electron microscopic autoradiography and diaminobenzidine cytochemistry provide evidence for an uptake and vesicular transport mechanism for iodine-125-labeled immunoglobulin A from plasma to bile by hepatocytes in vivo. The data confirm the existence of a hepatobiliary pathway for secretion of immunoglobulin A into the intestine and are consistent with a vesicular transport mechanism for biliary proteins within liver parenchymal cells.