Long-term effects of topical cyclosporine A treatment after penetrating keratoplasty
Long-term effects of topical cyclosporine A treatment after penetrating keratoplasty
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DOI：
10.1016/s0021-5155(99)00223-3
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发表时间：
2000-05-01
影响因子：
2.4
通讯作者：
Araie, M
中科院分区：
文献类型：
--
作者：
Inoue, K;Amano, S;Araie, M
目的：评价2%环孢素A （CsA）外用辅助皮质类固醇治疗穿透性角膜移植术（PKP）患者的长期疗效。方法：回顾性分析83例（86只眼）行PKP术后局部CsA治疗的病例，以及95例（97只眼）除2% CsA滴眼液外其他治疗的病例。作为控制组。患者还被细分为高风险组和低风险组。采用Kaplan-Meier法，通过移植物存活率和无排斥反应移植物存活率评估PKP的临床结局，并与log-rank检验进行比较。结果：在高危患者中。CsA组无排斥移植存活率为69.7%，对照组为45.4% (P = 0.030)，但两组移植存活率差异无统计学意义。结论：局部环孢素治疗可有效降低高危患者同种异体移植排斥反应的发生风险。中华眼科杂志2000；[4]中国眼科杂志。
Purpose: To evaluate the long-term outcome of topical 2% cyclosporine A (CsA) treatment as an adjunct to topical corticosteroid treatment of patients after penetrating keratoplasty (PKP).Methods: We reviewed the records of 83 patients (86 eyes) who had undergone PKP and received topical CsA treatment postoperatively: also the records of 95 PKP patients (97 eyes) who received the same treatment, except for the 2% CsA eyedrops. and served as controls. The patients were also subdivided into high-risk and low-risk groups. The clinical outcome of PKP was evaluated by the rates of graft survival and rejection-free graft survival, using the Kaplan-Meier method, and compared with the log-rank test.Results: In the high-risk patients. the rejection-free graft survival rate was 69.7% in the CsA group and 45.4% in the control group (P = .030), but there was no significant difference in the graft survival rate between the two groups.Conclusion: Topical cyclosporine treatment is effective in reducing the risk of allograft rejection in high-risk patients. Jpn J Ophthalmol 2000;44:302-305 (C) 2000 Japanese Ophthalmological Society.