Complementary and alternative medicine in pediatric allergic disorders.
Complementary and alternative medicine in pediatric allergic disorders.
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DOI：
10.1097/aci.0b013e328329226f
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发表时间：
2009-04
影响因子：
2.8
通讯作者：
Li XM
中科院分区：
文献类型：
--
作者：
Li XM
过敏性疾病是儿童中严重的公共卫生问题。这些疾病的慢性性质和对合成药物已知副作用的恐惧影响了许多家庭寻求补充和替代医学。本文综述了中药制剂、针灸治疗小儿过敏症的研究进展。鉴于一般的安全性和公认的疗效，中医药深受广大人群的欢迎。然而，相对于中医药的悠久历史和广泛使用，其有效性和安全性的研究仍处于起步阶段。近2-3年中医药治疗过敏性哮喘、过敏性鼻炎的对照研究较多。包括我们在内的一些出版物表明，一些中医草药配方是安全的，并产生了一定程度的疗效。一些中药配方也显示出有益的免疫调节作用。几项临床前研究表明，食物过敏草药配方-2（FAHF-2）在动物模型中对花生过敏反应有效。两种中药产品已进入美国临床试验阶段，分别用于治疗哮喘和食物过敏。这两项试验都包括儿童。近年来的研究表明，中医药疗法包括中药和针灸治疗儿童过敏性疾病是安全的。也有很有希望的临床和客观的改善。鼓励开展更多的对照临床研究。
Allergic disorders represent serious public health problem in children. The chronic nature of these diseases and the fear of known side effects of synthetic drugs influence many families to seek complementary and alternative medicine (CAM). This review focuses on TCM herbal products, acupuncture for treating paediatric allergies. Given the general safety profile, reputed efficacy, TCM are well received by the general population. However, compared to the long human use history and popularity of use of TCM, research into its efficacy and safety is still in infancy. Recent 2-3 years there are more controlled studies of TCM for allergic asthma, allergic rhinitis. Several publications including ours indicate that some TCM herbal formulas are safe and produced some levels of efficacy. Some herbal formula also showed beneficial immunomodualtory effects. Several preclinical studies demonstrated that the food allergy herbal formula-2 (FAHF-2) was effective in protecting against peanut anaphylaxis in animal model. Two TCM products have entered the clinical trials in the US for treating asthma and food allergy respectively. Both of these trials include children. Recently studies indicate that TCM therapy including herbal medicines and acupuncture for allergic disorders in children is safe. There are also promising clinical and objective improvement. More controlled clinical studies are encouraged.