Transient hemiageusia in cerebrovascular lateral pontine lesions
Transient hemiageusia in cerebrovascular lateral pontine lesions
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DOI：
10.1136/jnnp.2005.086801
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发表时间：
2006-05-01
影响因子：
11
通讯作者：
Landis, T
中科院分区：
文献类型：
--
作者：
Landis, BN;Leuchter, I;Landis, T
人类中央味觉通路的知识主要基于教科书（解剖解剖）和动物（体内电生理）数据。直到最近，人们才对人类中枢味觉通路的功能有了进一步的了解。磁共振成像研究，特别是对人类血管、肿瘤或炎症病变的选择性成像，使这成为可能。然而，一些问题仍然存在，特别是关于人类味觉影响的确切交叉点。我们报告了一位椎动脉血栓形成后脑桥中风的患者。患者小脑前下动脉供血区出现梗死，表现为垂直性复视、右侧耳聋、右侧面瘫和一过性偏音。本文对中枢性味觉障碍和中风后食物偏好改变的文献进行了综述，并以偏饮病例为重点。这个案例提供了新的证据，表明人类的中央味觉通路在脑桥内同侧运行，并在更高的，可能是中脑的水平上交叉。在中枢性病变的患者中，很少注意到味觉障碍。他们可能经常被医生和/或病人忽视。涉及味觉通路的中枢性病变似乎会产生定量味觉障碍（味觉偏缺或味觉减退）的感知，而周围性味觉病变则很难被患者识别为定量味觉障碍，但有时会被患者识别为定性味觉障碍（味觉障碍）。
Knowledge of human central taste pathways is largely based on textbook (anatomical dissections) and animal (electrophysiology in vivo) data. It is only recently that further functional insight into human central gustatory pathways has been achieved. Magnetic resonance imaging studies, especially selective imaging of vascular, tumoral, or inflammatory lesions in humans has made this possible. However, some questions remain, particularly regarding the exact crossing site of human gustatory afferences. We present a patient with a pontine stroke after a vertebral artery thrombosis. The patient had infarctions in areas supplied by the anterior inferior cerebellar artery and showed vertical diplopia, right sided deafness, right facial palsy, and transient hemiageusia. A review of the sparse literature of central taste disorders and food preference changes after strokes with a focus on hemiageusia cases is provided. This case offers new evidence suggesting that the central gustatory pathway in humans runs ipsilaterally within the pons and crosses at a higher, probably midbrain level. In patients with central lesions, little attention has been given to taste disorders. They may often go unnoticed by the physician and/or the patient. Central lesions involving taste pathways seem to generate perceptions of quantitative taste disorders (hemiageusia or hypogeusia), in contrast to peripheral gustatory lesions that are hardly recognised as quantitative but sometimes as qualitative (dysgeusia) taste disorders by patients.