Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study.
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study.
复制标题
腹主动脉瘤或直径相对较大的非动脉瘤主动脉会增加总死亡率和心血管死亡率：特罗姆瑟研究。
DOI：
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发表时间：
2010
影响因子：
7.7
通讯作者：
B. Jacobsen
中科院分区：
文献类型：
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作者：
S. Forsdahl;S. Solberg;Kulbir Singh;B. Jacobsen
背景
在挪威特罗莫斯的一项以人群为基础的研究中，作者评估了腹主动脉瘤(AAA)或非动脉瘤的肾下主动脉最大直径是否会影响总死亡率和心血管疾病(CVD)死亡率。
方法
共有6640名年龄在25-84岁的男性和女性参加了为期10年的死亡率随访：345名被诊断为AAA的受试者和6295名非动脉瘤的受试者。将非动脉瘤样主动脉直径和AAA发生率分为7组。
结果
在无AAA的受试者中，经年龄和性别调整后的总死亡率[死亡率比(MRR)=3.73，95%可信区间(CI)1.77~7.89]和心血管病死率(MRR=9.24，95%可信区间(CI)4.07~20.97)均高于主动脉直径<30 mm的受试者。筛查时AAA与主动脉瘤死亡密切相关，与总死亡率(MRR=1.60，95%可信区间1.31~1.96)和心血管死亡率(MRR=2.41，95%可信区间1.81~3.21)相关。这不能用AAA导致的死亡来解释。对心血管危险因素的调整可以完全解释AAA受试者总死亡率增加的原因，但不能解释心血管疾病死亡率的增加。
结论
AAA会增加总死亡率和心血管疾病死亡率。在绝大多数非动脉瘤样主动脉的受试者中，直径不会影响总死亡率或心血管疾病死亡率。然而，在最大直径>；26 mm(占总人口的2%)的个体中，发现了正相关关系。
BACKGROUND
In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality.
METHODS
A total of 6640 men and women, aged 25-84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and 6295 subjects with a non-aneurismal aorta. Non-aneurismal aortic diameter and prevalent AAAs were categorized into seven groups.
RESULTS
In subjects without an AAA, an aortic diameter > or =30 mm increased age- and sex-adjusted total mortality [mortality rate ratio (MRR) = 3.73, 95% confidence interval (CI) 1.77-7.89] and CVD mortality (MRR = 9.24, 95% CI 4.07-20.97) compared with subjects with aortic diameter of 21-23 mm. An AAA at screening was strongly associated with deaths from aortic aneurysm and was associated with total (MRR = 1.60, 95% CI 1.31-1.96) and CVD mortality (MRR = 2.41, 95% CI 1.81-3.21). This was not explained by deaths due to an AAA. Adjustments for CVD risk factors could fully explain the increased total, but not CVD mortality in subjects with an AAA.
CONCLUSIONS
An AAA increases total and CVD mortality. In the large majority of subjects with a non-aneurysmal aorta, the diameter does not influence total or CVD mortality. However, in individuals with a maximal diameter >26 mm (2% of the population), a positive relationship is found.