Hormonal factors and risk of lung cancer among women?
Hormonal factors and risk of lung cancer among women?
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DOI：
10.1093/ije/dyg064
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发表时间：
2003-04-01
影响因子：
7.7
通讯作者：
Wichmann, HE
中科院分区：
文献类型：
--
作者：
Kreuzer, M;Gerken, M;Wichmann, HE
背景 肺癌组织学分布的性别差异以及女性对烟草致癌物的易感性可能高于男性，表明性别特异性激素可能存在影响。本研究通过吸烟状况和组织学检查女性的内分泌因素和肺癌风险。方法我们使用1990年至1996年在德国进行的一项肺癌病例对照研究的数据，包括811例经组织学证实的女性病例和912例女性对照。使用结构化问卷进行个人访谈，收集有关各种月经和生殖因素、口服避孕药 (OC) 的使用、激素替代疗法 (HRT) 和吸烟的信息。通过逻辑回归计算调整年龄、地区、吸烟和教育程度的比值比 (OR) 和 95% CI。 结果 使用 OC 观察到肺癌风险降低（OR = 0.69；95% CI：0.51-0.92），但不存在随着使用时间、首次使用年龄或首次使用日历年的增加而出现风险的趋势。 HRT 病史与风险降低相关（OR = 0.83；95% CI：0.64-1.09），特别是在长期（大于或等于 7 年）后（OR = 0.59；95% CI：0.37-0.93）。没有发现与初潮年龄、月经周期长度、活产数量和绝经年龄之间存在明确的关联。总体结果因组织学细胞亚型的不同而没有太大差异。与使用外源激素相关的肺癌风险降低主要见于吸烟女性。结论我们的数据为激素因素在女性肺癌病因学中可能发挥的作用提供了证据。
Background Gender differences in the histological distribution of lung carcinoma and a possibly greater susceptibility of women than men to tobacco carcinogens, suggest a possible influence of sex-specific hormones. This study examines endocrine factors and risk of lung cancer among women by smoking status and histology.Methods We used data of a case-control study on lung cancer conducted from 1990 to 1996 in Germany, including 811 histologically confirmed female cases and 912 female population controls. Information on various menstrual and reproductive factors, use of oral contraceptives (OC), hormone replacement therapy (HRT), and smoking was gathered through personal interviews using a structured questionnaire. Odds ratios (OR) and 95% CI adjusted for age, region, smoking, and education were calculated via logistic regression.Results A reduction in lung cancer risk was observed with the use of OC (OR = 0.69; 95% CI: 0.51-0.92), but no trend in risk with increasing duration of use, age at first use, or calendar year of first use was present. A history of HRT was associated with a reduced risk (OR = 0.83; 95% CI: 0.64-1.09), particularly after long duration (greater than or equal to7 years) (OR = 0.59; 95% CI: 0.37-0.93). No clear association was found with regard to age at menarche, length of menstrual cycle, number of live-births, and age at menopause. Overall results did not differ much by histological cell subtype. The reduction in lung cancer risk associated with the use of exogenous hormones was primarily seen among smoking women.Conclusions Our data provide evidence for a possible role of hormonal factors in the aetiology of lung cancer in women.