Impact of sleep on the risk of cognitive decline and dementia.
Impact of sleep on the risk of cognitive decline and dementia.
复制标题
DOI：
10.1097/yco.0000000000000106
复制
发表时间：
2014-11
影响因子：
6.9
通讯作者：
Yaffe K
中科院分区：
文献类型：
--
作者：
Spira AP;Chen-Edinboro LP;Wu MN;Yaffe K
入睡困难或保持睡眠，睡眠质量差以及睡眠时间短或长作为认知能力下降和痴呆症（包括阿尔茨海默病（AD））的潜在风险因素越来越受到关注。睡眠呼吸障碍（SDB）也与这些结果有关。在这里，我们回顾了最近的观察和实验研究，调查睡眠不良对认知结果和AD的影响，并讨论了可能的机制。采用自我报告和客观睡眠测量的观察性研究（例如，腕动记录仪、多导睡眠记录仪）支持睡眠紊乱和认知能力下降之间的联系。最近发表的几项研究证明了睡眠变量与AD病理学指标之间的相关性，包括Aβ的脑脊液指标（CSF）和Aβ沉积的正电子发射断层扫描（PET）指标。此外，实验研究表明，睡眠不足会改变CSF Aβ动力学，慢波睡眠减少可能会减少Aβ从大脑中的清除，SDB特有的低氧血症会增加Aβ的产生。研究结果表明，睡眠不足是认知能力下降和AD的危险因素。虽然这些关联的机制尚不清楚，但健康的睡眠似乎在随着年龄的增长保持大脑健康方面发挥着重要作用，并可能在预防AD中发挥关键作用。
Trouble falling or staying asleep, poor sleep quality, and short or long sleep duration are gaining attention as potential risk factors for cognitive decline and dementia, including Alzheimer's disease (AD). Sleep-disordered breathing (SDB) has also been linked to these outcomes. Here, we review recent observational and experimental studies investigating the effect of poor sleep on cognitive outcomes and AD and discuss possible mechanisms. Observational studies with self-report and objective sleep measures (e.g., wrist actigraphy, polysomnography) support links between disturbed sleep and cognitive decline. Several recently published studies demonstrate associations between sleep variables and measures of AD pathology, including cerebrospinal fluid measures (CSF) of Aβ and positron emission tomography (PET) measures of Aβ deposition. In addition, experimental studies suggest that sleep loss alters CSF Aβ dynamics, that decrements in slow-wave sleep may decrease the clearance of Aβ from the brain, and that hypoxemia characteristic of SDB increases Aβ production. Findings indicate that poor sleep is a risk factor for cognitive decline and AD. Although mechanisms underlying these associations are not yet clear, healthy sleep appears to play an important role in maintaining brain health with age, and may play a key role in AD prevention.