Hallucinating schizophrenia patients have longer left arcuate fasciculus fiber tracks: a DTI tractography study
Hallucinating schizophrenia patients have longer left arcuate fasciculus fiber tracks: a DTI tractography study
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DOI：
10.1016/j.pscychresns.2020.111088
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发表时间：
2020-08-30
影响因子：
2.3
通讯作者：
Hugdahl, Kenneth
中科院分区：
文献类型：
--
作者：
Falkenberg, Liv E.;Westerhausen, Rene;Hugdahl, Kenneth
弓状束（AF）与精神分裂症和幻听（AVH）的病理学有关。形成弓状束的白色物质束可以使用扩散张量成像（DTI）纤维束成像进行定量和可视化。虽然有一些关于这个主题的研究，但结果是相互矛盾的。研究AF的潜在白色结构可以揭示AVH中颞叶和额叶语言区之间相互作用的限制。研究对象为66例精神分裂症患者，采用阳性和阴性症状量表（PANSS）评定AVH，并与健康对照组进行比较。在3T MR扫描机上进行DTI，采用确定性流线纤维束成像进行张量估计。数据的统计分析显示，严重和频繁AVH患者沿着AF的重建轨迹明显较长，并且与右侧相比，左侧的轨迹较长，总体上显著不对称。此外，PANSS评分与左侧后AF段的轨迹长度、轨迹体积和轨迹流线数之间存在显著正相关。它的结论是，目前的DTI结果可能有影响的功能成像结果的解释。
The arcuate fasciculus (AF) has been implicated in the pathology behind schizophrenia and auditory verbal hallucinations (AVHs). White matter tracts forming the arcuate fasciculus can be quantified and visualized using diffusion tensor imaging (DTI) tractography. Although there have been a number of studies on this topic, the results have been conflicting. Studying the underlying white matter structure of the AF could shed light on the constrains for interaction between temporal and frontal language areas in AVHs. The participants were 66 pa-tients with a schizophrenia diagnosis, where AVHs were defined from the Positive and Negative Syndrome Scale (PANSS), and compared with a healthy control group. DTI was performed on a 3T MR scanner, and tensor estimation was done using deterministic streamline tractography. Statistical analysis of the data showed sig-nificantly longer reconstructed tracks along the AF in patients with severe and frequent AVHs, as well as an overall significant asymmetry with longer tracks in the left compared to the right side. In addition, there were significant positive correlations between PANSS scores and track length, track volume, and number of track streamlines for the posterior AF segment on the left side. It is concluded that the present DTI results may have implications for interpretations of functional imaging results.