A Method of Error Suppression for Self-assembling DNA Tiles
A Method of Error Suppression for Self-assembling DNA Tiles
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DOI：
10.1007/11493785_10
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发表时间：
2004-06
影响因子：
1.3
通讯作者：
Kenichi Fujibayashi;S. Murata
中科院分区：
文献类型：
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作者：
Kenichi Fujibayashi;S. Murata
DNA自组装是分子计算的一种重要方法。在这种方法中，DNA瓦片自组装成一个大的二维晶格。互补链之间的C杂交。因此，杂交不是一个确定性的过程，而是一个随机的过程，它取决于瓷砖的浓度和温度。因此，它是di。获得一个没有误差的集合。骨料的生长速度必须非常低，以获得包含较少错误的骨料。Winfree等人提出了校对瓷砖模型（Proofreading Tile Model， PTM），该模型通过将瓷砖分割成小块来增强瓷砖规格，实现了低错误率和快速增长。的城市。然而，它仍然没有。因为它需要大量的完全正交的线。
Self-assembling DNA tile is an important method of molecular computation. In this method, DNA tiles self-assemble a large twodimensional lattice by the speci. c hybridization between complementary strands. Hence hybridization is not a deterministic, but stochastic, process which depends on tile concentration and temperature. For that reason, it is di. cult to obtain an aggregate with no error. Growth speed of the aggregate must be very low to obtain an aggregate that contains less errors. Winfree et al. proposed the Proofreading Tile Model (PTM), which achieves both a low error rate and fast growth speed by splitting tiles into pieces to enhance tile speci. city. However, it remains di. cult to implement because it requires a large set of completely orthogonal strands.