Body Composition and Metabolic Profile in Women with Complete Androgen Insensitivity Syndrome
Body Composition and Metabolic Profile in Women with Complete Androgen Insensitivity Syndrome
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DOI：
10.1159/000228719
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发表时间：
2009-01-01
影响因子：
2.3
通讯作者：
Bertelloni, S.
中科院分区：
文献类型：
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作者：
Dati, E.;Baroncelli, G. I.;Bertelloni, S.
临床和实验数据表明，雄激素受体(AR)信号转导通路对机体成分、血糖动态平衡和脂代谢起着重要作用。AR干扰对这些参数的影响在人类中还没有得到广泛的研究。对18例中青年女性完全雄激素不敏感综合征患者(CAI组，年龄32.2±-9.3岁；摘除睾丸组14例)进行了体重指数(BMI)、体成分(双能X线吸收法)、血糖水平、胰岛素敏感性(HOMA-IR)和血脂谱的检测。平均BMI(24.2+/-7.4 kg/m(2))没有显著增加(T-Score 1.0+/-2.5，p=NS vs意大利女性参考值)，但CAI女性肥胖率高于与年龄相关的意大利女性(分别为16.7%和3.6%)。大多数患有CAI的肥胖者属于睾丸完整的亚组(3/4)。DXA评估(n=15)显示，总游离脂肪质量与46，XX名女性对照组相似。与女性和男性对照组相比，CAIS女性的体脂增加。胆固醇(总胆固醇和低密度脂蛋白)和HOMA-IR的异常值在很大一部分患者中存在。我们的数据表明，在患有CAIS的女性中，AR信号的中断可能会增加体内脂肪，并影响一些代谢参数。随着年龄的增长，评估身体成分、代谢特征以及可能的心血管风险似乎是可取的。版权所有(C)2009 S.Karger AG，巴塞尔
Clinical and experimental data suggest that androgen receptor (AR) signaling plays a role on body composition, glucose homeostasis and lipid metabolism. The effect of AR disruption on such parameters was not extensively investigated in human people. A group of young to middle-age adult women with complete androgen insensitivity syndrome (CAIS, n = 18, age 32.2 +/- 9.3 years; women with testes removed n = 14) was investigated for body mass index (BMI), body composition (dual energy X-ray absorptiometry), serum glucose levels, insulin sensitivity (HOMA-IR) and lipid profile. Mean BMI (24.2 +/- 7.4 kg/m(2)) was not significantly increased (T-score 1.0 +/- 2.5, p = NS vs Italian female reference values), but prevalence of obesity was higher in women with CAIS than that reported in age-related Italian females (16.7% vs 3.6%, respectively). The majority of obese individuals with CAIS was in the subgroup with intact testes (3/4). DXA assessment (n = 15) demonstrated values of total free fat mass similar to that of 46, XX female controls. Increased body fat was found in CAIS women in comparison with both female and male controls. Abnormal values of cholesterol (total and LDL) and HOMA-IR were present in a large subset of patients. Our data suggest that in women with CAIS disruption of AR signaling may increase body fat and affect some metabolic parameters. Assessment of body composition, metabolic profile and, likely, cardiovascular risk seems to be advisable with ageing in these individuals. Copyright (C) 2009 S. Karger AG, Basel