THE EFFECTS OF ENDURANCE EXERCISE ON DYSTROPHIC MDX MICE .1. CONTRACTILE AND HISTOCHEMICAL PROPERTIES OF INTACT MUSCLES
THE EFFECTS OF ENDURANCE EXERCISE ON DYSTROPHIC MDX MICE .1. CONTRACTILE AND HISTOCHEMICAL PROPERTIES OF INTACT MUSCLES
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DOI：
10.1098/rspb.1993.0077
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发表时间：
1993-07-22
影响因子：
4.7
通讯作者：
WILLIAMS, DA
中科院分区：
文献类型：
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作者：
HAYES, A;LYNCH, GS;WILLIAMS, DA
基因正常 (C57BL/10) 和营养不良 (mdx) 小鼠接受了为期 15 周的耐力游泳计划（每天 2 小时，每周 5 天），其中在大多数疗程中对动物进行称重（5% 体重）。在运动方案之后，对照小鼠的肌肉收缩特性或形态没有观察到显着变化。相反，与久坐的 mdx 小鼠相比，运动的 mdx 小鼠的比目鱼肌表现出更高的标准化张力，并且趾长伸肌 (EDL) 表现出更长的半松弛时间。 mdx 小鼠的 EDL 和比目鱼肌在耐力运动后表现出抗疲劳能力增强。与正常品系的动物相比，久坐的 mdx 小鼠在比目鱼肌中表现出 I 型（慢氧化）纤维的比例增加，在 EDL 中 IIA 型（快速氧化糖酵解）纤维的比例增加。在训练计划结束后，mdx 小鼠的 EDL 和比目鱼肌中 I 型纤维的比例明显更高。耐力运动对mdx小鼠有益，通过增加氧化纤维的比例和降低肌肉疲劳性来增强其肌肉功能的再生。
Genetically normal (C57BL/10) and dystrophic (mdx) mice underwent a 15 week endurance swimming programme (2 hours per day, 5 days per week) where animals were weighted (5 % body weight) during most sessions. No significant changes were seen in the contractile properties or morphology of muscles from control mice following the exercise protocol. In contrast, the soleus muscles of exercised mdx mice displayed higher normalized tensions, and the extensor digitorum longus (EDL) exhibited longer half-relaxation times compared with sedentary mdx mice. Both the EDL and soleus muscles of mdx mice exhibited increased resistance to fatigue after endurance exercise. Sedentary mdx mice exhibited increased proportions of type I (slow oxidative) fibres in the soleus and type IIA (fast, oxidative glycolytic) fibres iii the EDL compared with animals of the normal strain. In both the EDL and soleus muscles of mdx mice an even greater proportion of type I fibres was apparent following the training programme. The endurance exercise was beneficial to the mdx mice, enhancing the regeneration of function of their muscles by increasing the proportion of oxidative fibres and reducing muscle fatiguability.