Blood flow distribution in the normal human preterm brain
Blood flow distribution in the normal human preterm brain
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DOI：
10.1203/00006450-199801000-00005
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发表时间：
1998-01-01
影响因子：
3.6
通讯作者：
Greisen, G
中科院分区：
文献类型：
--
作者：
Borch, K;Greisen, G
脑血流紊乱(CBF)是新生儿脑损伤病因和发病机制中的一个重要因素。由于大多数动物在出生时比人类更成熟，从动物研究到人类的推断是值得怀疑的。因此。我们测量了早产儿的局部脑血流量(RCBF)。对12例血压正常、缺氧的早产儿[平均出生体重915g(550~2680g)，平均胎龄27.7wk(25~32wk)]进行rCBF测定。所有婴儿都进行了正常的脑部超声检查，使用专门为新生儿研究设计的移动式脑专用快速旋转四头多探测器系统测量rCBF。示踪剂为~(99m)Tc标记的D，L-六亚甲基丙胺肟，剂量为4MBq/kg。皮质下白质的rCBF为全球CBF的0.53(0.48~0.58)。经散射辐射校正后，rCBF对白质的估计值降至0.39(0.36~0.42)。流向基底节的血流量是整体脑血流量的2.33(2.08-2.59)倍。校正部分体积效应后，皮质血流量高于流向基底节的血流量，额颞叶(运动皮质)血流量最高。流向小脑的流量与流向基底节的流量相同，但差异显著。12例早产儿的rCBF表现出与其他新生哺乳动物相似的血流分布。然而，灰白色物质的对比度更大。这一新信息，结合现有数据显示全球脑血流量较低，表明血液对早产儿脑白质的影响极低。
Disturbances in cerebral blood how (CBF) are a major factor in the etiology and pathogenesis of cerebral damage in the neonate. As most animals are more mature at birth than man, extrapolation from animal studies to the human is questionable. Therefore. we have measured regional CBF (rCBF) in preterm infants. rCBF flow was measured in 12 normotensive and normoxic preterm infants [mean birth weight 915 g (range 550 to 2680 g), mean gestational age 27.7 wk (25 to 32 wk)]. All infants had a normal cerebral ultrasound examination, rCBF was measured using a mobile brain dedicated fast-rotating four-head multidetector system specially designed for neonatal studies. The tracer was Tc-99m-labeled D,L-hexamethylpropylenamine oxime in a dose of 4 Mbq/kg. rCBF of the subcortical white matter was 0.53 (0.48-0.58) of the global CBF. After correction for scattered radiation, the estimate of rCBF to the white matter was reduced to 0.39 (0.36-0.42). The flow to the basal ganglia was 2.33 (2.08-2.59) times the global CBF. After correction for partial volume effect, the cortical flow was higher than the flow to the basal ganglia and highest in the frontotemporal cortex (motor cortex). The flow to the cerebellum was of the same magnitude as the flow to the basal ganglia, but with a significantly higher variation. rCBF in 12 preterm infants showed a flow distribution similar to flow in other newborn mammals. The gray-white matter contrast, however, was greater. This new information, combined with existing data showing low global CBF, suggests that blood how to the white matter in the preterm human neonate is extremely low.