Mutants affecting position-effect heterochromatinization in Drosophila melanogaster
Mutants affecting position-effect heterochromatinization in Drosophila melanogaster
复制标题
影响果蝇位置效应异染色质化的突变体
作者：
G. Reuter;W. Werner;H. Hoffmann
显性抑制子Su（var）b101和显性增强子En（var）c101被发现对wm 4染色体的强杂色系（wm 4 h）的白色杂色有显著影响，这已被用作位置效应杂色遗传分析的标准重排（罗伊特和Wolff，1981）。这两种突变也被证明会影响T（1;4）wm 258 - 21中的位置效应异染色质化和所有测试的重排中的杂色（白色、棕色、盾形和短形杂色）。这些结果表明，基因识别编码的功能是必不可少的表现基因失活的位置效应重排。这似乎也合理的假设，在所有的重排测试相同的异染色质化过程导致失活的基因，其表型是多样化的。
The dominant suppressor Su(var)b101 and the dominant enhancer En(var)c101 were found to affect significantly white variegation in a strongly variegating line of the wm4chromosome (wm4h) which has been used as standard rearrangement for a genetic dissection of position-effect variegation (Reuter and Wolff, 1981). Both mutations were also shown to affect position-effect heterochromatisation in T(1;4)wm258-21and variegation in all the rearrangements tested (white, brown, scute and bobbed variegation). These results suggest that the genes identified encode functions essential for the manifestation of gene inactivation in position-effect rearrangements. It seems also reasonable to assume that in all the rearrangements tested identical heterochromatisation processes lead to inactivation of the genes whose phenotype is variegated.