Emergence of Genotype I of Japanese Encephalitis Virus as the Dominant Genotype in Asia
Emergence of Genotype I of Japanese Encephalitis Virus as the Dominant Genotype in Asia
复制标题
日本脑炎病毒基因型 I 成为亚洲优势基因型
DOI：
10.1128/jvi.00825-11
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发表时间：
2011-10-01
影响因子：
5.4
通讯作者：
Liang, Guo-Dong
中科院分区：
文献类型：
--
作者：
Pan, Xiao-Ling;Liu, Hong;Liang, Guo-Dong
摘要日本脑炎病毒(JEV)是一种由蚊媒传播的人畜共患病病原体，是世界范围内病毒性脑炎的主要病原之一。以前基于包膜蛋白的系统发育研究表明，有四种基因类型，监测数据表明，基因I正在逐渐取代基因III成为优势菌株。在这里，我们报告了基于98个乙脑病毒全长基因组序列的进化分析，其中包括从人、猪、蚊子、蚊子和蚊子中分离的67个新样本。以及受影响地区的蝙蝠。为了研究基因分型和基因I在近期流行中的重要性之间的关系，我们估计了进化率、共同祖先的年龄和人口统计学。结果表明，各型的遗传多样性依次为IV、III、II、I型，且III型的遗传多样性迅速下降，而I型的遗传多样性逐渐增加，这与其成为优势基因相一致。
ABSTRACT Japanese encephalitis virus (JEV), a mosquito-borne zoonotic pathogen, is one of the major causes of viral encephalitis worldwide. Previous phylogenetic studies based on the envelope protein indicated that there are four genotypes, and surveillance data suggest that genotype I is gradually replacing genotype III as the dominant strain. Here we report an evolutionary analysis based on 98 full-length genome sequences of JEV, including 67 new samples isolated from humans, pigs, mosquitoes, midges. and bats in affected areas. To investigate the relationships between the genotypes and the significance of genotype I in recent epidemics, we estimated evolutionary rates, ages of common ancestors, and population demographics. Our results indicate that the genotypes diverged in the order IV, III, II, and I and that the genetic diversity of genotype III has decreased rapidly while that of genotype I has increased gradually, consistent with its emergence as the dominant genotype.