Hypervalent Iodine-mediated Cascade Annulation of Diarylalkynes Forming Spiro Heterocycles under Metal-free Conditions
Hypervalent Iodine-mediated Cascade Annulation of Diarylalkynes Forming Spiro Heterocycles under Metal-free Conditions
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无金属条件下高价碘介导的二芳基炔的级联环化形成螺杂环
DOI：
10.1002/chem.201406393
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Du Yunfei
中科院分区：
文献类型：
--
作者：
Zhang Xiang;Yang Chao;Zhang-Negrerie Daisy;Du Yunfei
以高价碘试剂为唯一氧化剂，首次实现了一个不寻常的反应，其特征是内炔的级联成环，得到螺杂环作为产物。这个前所未有的过程不仅包括两个连续的C N/C O-键的形成，而且还包括羰基氧的插入，所有这些都在无金属条件下在一个锅中进行。
An unusual reaction featuring the cascade annulation of internal alkynes to afford spiro heterocycles as the products has been realized for the first time with a hypervalent iodine reagent as the only oxidant. This unprecedented process encompasses not only two sequential CN/CO‐bond formations, but also the insertion of a carbonyl oxygen, all in one pot under metal‐free conditions.