Positive and Negative Regulators of Sclerostin Expression.
Positive and Negative Regulators of Sclerostin Expression.
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DOI：
10.3390/ijms23094895
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发表时间：
2022-04-28
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
硬化蛋白由骨细胞分泌，与Wnt共受体Lrp 5/6结合，并影响Wnt配体与Lrp 5/6之间的相互作用，从而抑制Wnt/β-连环蛋白信号并抑制骨形成。硬化蛋白作为骨形成的负调节因子，在骨量保存中起重要作用。硬化蛋白缺乏引起硬化性骨病，其特征在于在人和小鼠中具有增强的骨形成的过量骨量。骨硬化素的表达受多种因素的正性和负性调节，这些因素也支配骨代谢。本文根据最近和以前的研究结果，包括我们的研究，介绍和讨论了sclerostin表达的正调控因子和负调控因子及其作用。
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the preservation of bone mass by functioning as a negative regulator of bone formation. A sclerostin deficiency causes sclerosteosis, which is characterized by an excess bone mass with enhanced bone formation in humans and mice. The expression of sclerostin is positively and negatively regulated by many factors, which also govern bone metabolism. Positive and negative regulators of sclerostin expression and their effects are introduced and discussed herein based on recent and previous findings, including our research.