The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster
The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster
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DOI：
10.1007/s00427-004-0452-y
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发表时间：
2005-02-01
影响因子：
2.4
通讯作者：
Okano, H
中科院分区：
文献类型：
--
作者：
Hirota, Y;Sawamoto, K;Okano, H
我们以前克隆和表征果蝇基因，tinar（tinc），它编码一种新的蛋白质与8个假定的跨膜结构域。在此，我们研究了tinc在发育过程中的表达模式和功能。tinc mRNA在胚胎发育期间在中枢和外周神经系统以及中肠中表达。在三龄幼虫眼盘，TINC mRNA强烈表达在所有分化小眼细胞内和附近的形态发生沟。使用RNA干扰方法的功能丧失分析揭示了在发育后期眼睛形态发生的严重缺陷。我们的研究结果表明，tinc可能在小眼细胞的正常分化中起着不可或缺的作用。
We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.