Irritable bowel syndrome in twins: genes and environment
Irritable bowel syndrome in twins: genes and environment
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DOI：
10.1136/gut.2006.097287
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发表时间：
2006-12-01
期刊：
影响因子：
24.5
通讯作者：
Harris, J. R.
中科院分区：
文献类型：
--
作者：
Bengtson, M. -B.;Ronning, T.;Harris, J. R.
背景和目的：环境和遗传因素都可能导致肠易激综合征（IBS）。胎儿生命中的营养是一种早期环境因素，似乎会影响以后生活中慢性疾病的发展，例如冠心病、高血压和非胰岛素糖尿病。这项基于人群的双胞胎研究评估了子宫内生长（通过体重和胎龄衡量）与肠易激综合征（IBS）之间的关联。通过结构方程分析来分析 IBS 易感性变异的遗传和环境来源。方法：向 1967 年至 1979 年间出生的 12 700 名挪威双胞胎发送了一份邮寄调查问卷。调查问卷包括 31 种疾病和症状的清单，其中包括 IBS。在四个体重组中测试了出生体重对发生肠易激综合症的影响。对疾病不一致的同卵双胞胎 (MZ) 进行分析，以测试宫内生长与 IBS 之间的关联。结果：同卵双胞胎 (22.4%) 的 IBS 一致性显着高于异卵双胞胎 (9.1%) (p = 0.011)。据估计，女性 IBS 的遗传率为 48.4%。出生体重低于 1500 克（调整后优势比 2.4（95% 置信区间 1.1、5.3））对 IBS 的发生有显着影响，比较高体重组的 IBS 出现时间早 7.7 年。在出生体重低于 2500 g 的 MZ 组中，患有 IBS 的双胞胎明显轻于未患病双胞胎 (190.6 g；p = 0.02)。 结论：本研究表明，胎儿生长受限对以后 IBS 的发展具有显着影响。体重低于 1500 克会影响发病年龄。遗传因素似乎对女性肠易激综合症很重要。
Background and aims: Both environmental and genetic factors may contribute to irritable bowel syndrome (IBS). Nutrition in fetal life, an early environmental factor, seems to influence the development of chronic diseases later in life, such as coronary heart disease, hypertension, and non-insulin diabetes. This population based twin study evaluated the association between intrauterine growth, measured by weight and gestational age, and IBS. Structural equation analyses were conducted to analyse genetic and environmental sources of variation in liability to IBS.Methods: A postal questionnaire was sent to 12 700 Norwegian twins born between 1967 and 1979. The questionnaire included a checklist of 31 illnesses and symptoms, including IBS. The influence of birth weight on developing IBS was tested in four weight groups. Disease discordant monozygotic (MZ) pairs were analysed to test the association between intrauterine growth and IBS.Results: Concordance for IBS was significantly greater (p = 0.011) in monozygotic (22.4%) than in dizygotic (9.1%) twins. The heritability of IBS was estimated to be 48.4% among females. Birth weight below 1500 g (adjusted odds ratio 2.4 (95% confidence interval 1.1, 5.3)) contributed significantly to the development of IBS, which appeared 7.7 years earlier than in higher weight groups. In the MZ group with birth weights lower than 2500 g, twins with IBS were significantly lighter than twins without disease (190.6 g; p = 0.02).Conclusion: The present study demonstrates that restricted fetal growth has a significant influence on the development of IBS later in life. Weight below 1500 g influences age at onset. Genetic contribution appears to be important for IBS among females.