The wis1 protein kinase is a dosage‐dependent regulator of mitosis in Schizosaccharomyces pombe.
The wis1 protein kinase is a dosage‐dependent regulator of mitosis in Schizosaccharomyces pombe.
复制标题
wis1 蛋白激酶是粟酒裂殖酵母有丝分裂的剂量依赖性调节剂。
作者：
E. Warbrick;P. Fantes
The wis1+ gene encodes a newly identified mitotic control element in Schizosaccharomyces pombe. It was isolated by virtue of its interaction with the mitotic control genes cdc25, wee1 and win1. The wis1+ gene potentially encodes a 66 kDa protein with homology to the serine/threonine family of protein kinases. wis1+ plays an important role in the regulation of entry into mitosis, as it shares with cdc25+ and nim1+/cdr1+ the property of inducing mitosis in a dosage‐dependent manner. Increased levels of wis1+ expression cause mitotic initiation to occur at a reduced cell size. Loss of wis1+ function does not prevent vegetative growth and division, though wis1‐ cells show an elongated morphology, indicating that their entry into mitosis and cell division is delayed relative to wild type cells. wis1‐ cells undergo a rapid reduction of viability upon entry into stationary phase, suggesting a role for wis1+ in the integration of nutritional sensing with the control over entry into mitosis.
