Zinc homeostasis in humans
Zinc homeostasis in humans
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DOI：
10.1093/jn/130.5.1360s
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发表时间：
2000-05-01
影响因子：
4.2
通讯作者：
Woodhouse, LR
中科院分区：
文献类型：
--
作者：
King, JC;Shames, DM;Woodhouse, LR
维持细胞锌营养的恒定状态或内稳态对于正常功能是必不可少的。在动物和人类中，锌吸收和内源性肠道排泄的调节是维持锌稳态的主要手段，胃肠道锌吸收和内源性排泄的调节是协同的。内源性排泄的变化似乎随着摄入量的变化而迅速发生，而摄入量仅高于或低于最佳摄入量。锌的吸收反应较慢，但它有能力科普摄入量的大幅波动。极低的锌摄入量或长期的边缘摄入量，二次稳态调节可能会增加胃肠道的变化。这些二级调节包括尿锌排泄的变化、血浆锌周转率的变化，以及可能将从选定组织（例如骨骼）释放的锌大量保留在其他组织中以维持功能。
Maintaining a constant state of cellular zinc nutrition, or homeostasis, is essential for normal function. In animals and humans, adjustments in zinc absorption and endogenous intestinal excretion are the primary means of maintaining zinc homeostasis, The adjustments in gastrointestinal zinc absorption and endogenous excretion are synergistic. Shifts in endogenous excretion appear to occur quickly with changes in intake just above or below optimal intake. The absorption of zinc responds more slowly, but it has the capacity to cope with large fluctuations in intake. With extremely low zinc intakes or with prolonged marginal intakes, secondary homeostatic adjustments may augment the gastrointestinal changes. These secondary adjustments include changes in urinary zinc excretion, a shift in plasma zinc turnover rates and, possibly, an avid retention of zinc released from selected tissues, such as bone, in other tissues to maintain function.