Cortical representation of experimental tooth pain in humans
Cortical representation of experimental tooth pain in humans
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DOI：
10.1016/j.pain.2005.09.017
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发表时间：
2005-12-05
期刊：
影响因子：
7.4
通讯作者：
Forster, C
中科院分区：
文献类型：
--
作者：
Jantsch, HHF;Kemppainen, P;Forster, C
采用功能磁共振成像（fMRI）技术研究了健康志愿者牙髓电刺激痛的皮层处理过程。在第一个实验中，牙齿疼痛的皮层代表与疼痛的机械刺激的手进行了比较。对侧的S1皮层被激活，在痛苦的机械刺激的手，而牙痛导致双边激活的S1。S2和岛状区被这两种刺激双侧激活。在S2中，与牙痛相比，疼痛机械刺激期间激活的重心更靠近内侧/后侧。在岛状区，牙痛引起更强的激活的前部和内侧部分。手的疼痛刺激更强烈地激活前扣带回的后部。在运动区和额叶区也发现了差异激活，包括眶额叶皮质，牙痛导致更大的激活。在第二个实验中，我们比较了弱牙痛和强牙痛的效果。一个显着更大的激活，更痛苦的牙齿刺激被发现在大多数的这些地区，其中牙痛引起更多的激活比手痛。在内侧额回和右侧上级额回，我们发现疼痛强度和BOLD对比度之间呈反比关系。我们的结论是，牙痛激活的皮质网络，这是在几个方面不同的手的痛苦的机械刺激激活，不仅在躯体组织的体感区，但也在部分的“内侧”疼痛投射系统。(c)2005年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
Cortical processing of electrically induced pain from the tooth pulp was studied in healthy volunteers with fMRI. In a first experiment, cortical representation of tooth pain was compared with that of painful mechanical stimulation to the hand. The contralateral S 1 cortex was activated during painful mechanical stimulation of the hand, whereas tooth pain lead to bilateral activation of S1. The S2 and insular region were bilaterally activated by both stimuli. In S2, the center of gravity of the activation during painful mechanical stimulation was more medial/posterior compared to tooth pain. In the insular region, tooth pain induced a stronger activation of the anterior and medial parts. The posterior part of the anterior cingulate gyrus was more strongly activated by painful stimulation of the hand. Differential activations were also found in motor and frontal areas including the orbital frontal cortex where tooth pain lead to greater activations. In a second experiment, we compared the effect of weak with strong tooth pain. A significantly greater activation by more painful tooth stimuli was found in most of those areas in which tooth pain had induced more activation than hand pain. In the medial frontal and right superior frontal gyri, we found an inverse relationship between pain intensity and BOLD contrast. We concluded that tooth pain activates a cortical network which is in several respects different from that activated by painful mechanical stimulation of the hand, not only in the somatotopically organized somatosensory areas but also in parts of the 'medial' pain projection system. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.