Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells
Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells
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DOI：
10.1039/c1ob06094e
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Shen, Jingkang
中科院分区：
文献类型：
--
作者：
Ding, Derong;Zhang, Baozi;Shen, Jingkang
对新型黄芩素衍生物的抗增殖活性研究表明，化合物8和9能够通过提高磷酸化的AMPK α水平来激活AMPK，并且在A431、SK-OV-3、DU 145和HeLa细胞中表现出比黄芩素和AICAR更强的抗增殖作用，提示黄芩素在癌症治疗中的替代方法。
Studies on the anti-proliferative activities of novel baicalein derivatives demonstrated that compounds 8 and 9 were able to activate AMPK by enhancing the levels of phosphorylated AMPK alpha, and showed more potent anti-proliferative effects than baicalein and AICAR in A431, SK-OV-3, DU 145 and HeLa cells, suggesting an alternative therapeutic approach for benzyl baicalein in cancer therapy.