Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.
Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.
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发表时间：
1993-12
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通讯作者：
Yoshiyuki Nakamura;Y. Horii;T. Nishino;H. Shiiki;Y. Sakaguchi;T. Kagoshima;K. Dohi;Z. Makita
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作者：
Yoshiyuki Nakamura;Y. Horii;T. Nishino;H. Shiiki;Y. Sakaguchi;T. Kagoshima;K. Dohi;Z. Makita
晚期糖基化终产物(AGEs)聚集在长寿的细胞外基质蛋白上，与糖尿病的微血管和大血管并发症有关。在动脉壁内，AGE修饰的蛋白质增加血管通透性，灭活一氧化氮活性，并诱导促进生长的细胞因子的释放。最近开发的抗AGE抗体被用于从II型糖尿病患者和非糖尿病患者获得的冠状动脉的免疫组织化学分析。从选定的糖尿病患者的血管中观察到动脉粥样硬化斑块中存在高水平的AGE反应性。考虑到AGEs对血管壁稳态的病理影响，这些数据支持晚期糖基化在糖尿病相关的快速进展的动脉粥样硬化中的作用。
Advanced glycosylation end products (AGEs) accumulate on long-lived extracellular matrix proteins and have been implicated in the micro- and macrovascular complications of diabetes mellitus. Within the arterial wall, AGE-modified proteins increase vascular permeability, inactivate nitric oxide activity, and induce the release of growth-promoting cytokines. Recently developed anti-AGE antibodies were used in an immunohistochemical analysis of coronary arteries obtained from type II diabetic and nondiabetic patients. High levels of AGE reactivity were observed within the atherosclerotic plaque present in vessels from selected patients with diabetes. Considered together with the pathological effects of AGEs on vascular wall homeostasis, these data support the role of advanced glycosylation in the rapidly progressive atherosclerosis associated with diabetes mellitus.