Serum carcinoembryonic antigen-related cell adhesion molecule 1 level in postmenopausal women: correlation with β-catenin and bone mineral density
Serum carcinoembryonic antigen-related cell adhesion molecule 1 level in postmenopausal women: correlation with β-catenin and bone mineral density
复制标题
绝经后妇女血清癌胚抗原相关细胞粘附分子1水平：与β-连环蛋白和骨矿物质密度的相关性
DOI：
10.1007/s00198-015-3408-3
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发表时间：
2016-04-01
影响因子：
4
通讯作者：
Li，C. G.
中科院分区：
文献类型：
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作者：
Ma，C.;Shuai，B.;Li，C. G.
许多流行病学研究表明，在某些肿瘤中，癌胚抗原相关细胞粘附分子1（CEACAM 1）和β-连环蛋白（β-catenin）似乎存在相关性。然而，CEACAM 1是否与骨质疏松症中的β-连环蛋白相关仍有待确定。本研究旨在探讨绝经后妇女血清CEACAM 1水平及其与β-catenin和骨密度（BMD）的相关性，并探讨CEACAM 1与β-catenin在绝经后妇女骨代谢中的作用。检测350例绝经后妇女血清CEACAM 1、β-catenin、RANKL、OPG、β-CTX、PINP、雌二醇和胰岛素水平。患者分为根据腰椎或股骨颈T-评分为骨质疏松症（组I），骨量减少（组II），和正常的骨密度，后者作为control.ResultsCEACAM1水平显着降低，在组I和II相比，在对照组（P< 0.001）。血清CEACAM 1水平与β-catenin、BMD呈正相关，与RANKL/OPG比值呈负相关。结论血清CEACAM 1水平降低与绝经后妇女低BMD有关，血清CEACAM 1水平与β-catenin呈正相关。提示CEACAM 1可能通过影响经典的Wnt/β-catenin通路来调节骨代谢。
SummaryMany epidemiological studies have shown that in some tumors carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and β-catenin appear to be related. However, it remains to be established whether CEACAM1 is related to β-catenin in osteoporosis. Here, we reveal that CEACAM1 might influence the canonical Wnt/β-catenin pathway to modulate bone metabolism in postmenopausal osteoporosis.IntroductionThe aim of this study is to assess the serum level of CEACAM1 in postmenopausal women and its correlation with β-catenin and bone mineral density (BMD).MethodsThe BMD was measured at the lumbar spine (L1–L4) or the femoral neck using dual-energy X-ray absorptiometry (DXA). Serum CEACAM1, β-catenin, receptor activator of nuclear factor kappa-B (RANKL), osteoprotegerin (OPG), β-isomerized C-terminal crosslinking of type I collagen (β-CTX), intact N-terminal propeptide of type I collagen (PINP), estradiol, and insulin were measured in 350 postmenopausal women. Patients were divided according to lumbar spine or femur neck T-scores into osteoporosis (group I), osteopenia (group II), and normal bone mineral density, the latter serving as control.ResultsSerum CEACAM1 levels were significantly lower in group I and II compared to those in control subjects (P< 0.001). Serum CEACAM1 levels correlated positively with β-catenin and BMD, but correlated negatively to the ratio between RANKL and OPG.ConclusionThis study provides evidence that decreased serum CEACAM1 levels are related to low BMD in postmenopausal women, and that serum CEACAM1 levels correlated positively to β-catenin. It suggests that CEACAM1 might influence the canonical Wnt/β-catenin pathway to modulate bone metabolism.