Redox state of cytochrome c regulates cellular ROS and caspase cascade in permeablized cell model.
Redox state of cytochrome c regulates cellular ROS and caspase cascade in permeablized cell model.
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DOI：
10.2174/092986608783489490
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发表时间：
2008-01
影响因子：
1.6
通讯作者：
Min Li;Ao-Jin Wang;Jianxing Xu
中科院分区：
文献类型：
--
作者：
Min Li;Ao-Jin Wang;Jianxing Xu
在透化细胞系统中，氧化型细胞色素 c 能够诱导 caspase 级联，而还原细胞色素 c 则不能。在体外实验中，氧化细胞色素c可以促进H(2)O(2)的生成。这表明细胞色素c的氧化还原状态可能通过调节细胞ROS水平来调节细胞凋亡的启动。
In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H(2)O(2) generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.