Anterior thalamic lesions alter both hippocampal-dependent behavior and hippocampal acetylcholine release in the rat
Anterior thalamic lesions alter both hippocampal-dependent behavior and hippocampal acetylcholine release in the rat
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DOI：
10.1101/lm.023887.111
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发表时间：
2011-12-01
影响因子：
2
通讯作者：
Vetreno, Ryan P.
中科院分区：
文献类型：
--
作者：
Savage, Lisa M.;Hall, Joseph M.;Vetreno, Ryan P.
丘脑前核（ATN）对学习和记忆很重要，因为该区域的损伤会产生持续性遗忘综合征。ATN和海马之间存在密集的连接，重要的是，ATN的损伤会损害海马的功能。乙酰胆碱（Acetylcholine，ACh）是海马中一种重要的神经递质，体内ACh的测定与学习记忆能力密切相关。在本研究中，完全病变的ATN受损的性能上的两个措施，海马依赖的学习和记忆（自发交替和延迟交替）和严重破坏行为诱发的乙酰胆碱流出成年雄性大鼠海马内。与此相反，不完全ATN病变不损害自发交替性能，但损害延迟交替性能，同时钝化海马乙酰胆碱流出。有趣的是，任何大小的ATN病变都不影响海马中ACh的基础浓度。这些结果表明，ATN具有调节海马内行为相关神经元传递的能力。
The anterior thalamic nuclei (ATN) are important for learning and memory as damage to this region produces a persistent amnestic syndrome. Dense connections between the ATN and the hippocampus exist, and importantly, damage to the ATN can impair hippocampal functioning. Acetylcholine (ACh) is a key neurotransmitter in the hippocampus, and in vivo measures of ACh are correlated to learning and memory performance. In the present study, complete lesions of the ATN impaired performance on two measures of hippocampal-dependent learning and memory (spontaneous alternation and delayed alternation) and severely disrupted behaviorally evoked ACh efflux within the hippocampus of adult male rats. In contrast, incomplete ATN lesions did not impair spontaneous alternation performance but did impair delayed alternation performance while blunting hippocampal ACh efflux. Interestingly, ATN lesions of any size did not affect basal concentrations of ACh in the hippocampus. These results demonstrate that the ATN have the capacity to modulate behaviorally relevant neuronal transmission within the hippocampus.