Pathogen Inhibition by Multivalent Ligand Architectures
Pathogen Inhibition by Multivalent Ligand Architectures
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DOI：
10.1021/jacs.5b12950
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发表时间：
2016-07-20
影响因子：
15
通讯作者：
Haag, Rainer
中科院分区：
文献类型：
--
作者：
Bhatia, Sumati;Camacho, Luis Cuellar;Haag, Rainer
在病原体-细胞界面处的界面多价相互作用可以被多价支架竞争性地抑制，所述多价支架在感染的初始阶段防止病原体粘附到细胞。由于对复杂生物系统缺乏了解，设计有效的多价抑制剂成为一项艰巨的任务。因此，我们强调了与在界面处阻断病原体相关的主要问题和担忧，这取决于多价抑制剂和病原体（如病毒和细菌）的性质和特性。与多价抑制剂的不同核心或载体支架相关的挑战与选定的例子进行了简要讨论。
Interfacial multivalent interactions at pathogen-cell interfaces can be competitively inhibited by multivalent scaffolds that prevent pathogen adhesion to the cells during the initial stages of infection. The lack of understanding of complex biological systems makes the design of an efficient multivalent inhibitor a toilsome task. Therefore, we have highlighted the main issues and concerns associated with blocking pathogen at interfaces, which are dependent on the nature and properties of both multivalent inhibitors and pathogens, such as viruses and bacteria. The challenges associated with different cores or carrier scaffolds of multivalent inhibitors are concisely discussed with selected examples.