Enzyme-catalyzed oligosaccharide synthesis.
Enzyme-catalyzed oligosaccharide synthesis.
复制标题
酶催化寡糖合成。
DOI：
10.1016/0003-2697(92)90099-s
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发表时间：
1992
影响因子：
2.9
通讯作者：
Wong,CH
中科院分区：
文献类型：
--
作者：
Ichikawa,Y;Look,GC;Wong,CH
细胞表面碳水化合物及其结合物参与多种类型的分子识别。本文综述了酶催化低聚糖合成的最新进展，重点介绍了糖基转移酶和糖苷酶反应。随着糖基转移酶在重组DNA技术中的应用，糖基转移酶催化的糖基化和糖核苷酸的原位再生似乎是大规模立体控制低聚糖合成的最有效方法。
Cell-surface carbohydrates and their conjugates are involved in many types of molecular recognition. This review describes recent developments in enzyme-catalyzed oligosaccharide synthesis, with particular focus on glycosyltransferase and glycosidase reactions. With the increasing availability of glycosyltransferases via recombinant DNA technology, glycosyltransferase-catalyzed glycosylation with in situ regeneration of sugar nucleotides appears to be the most effective method for large-scale stereocontrolled oligosaccharide synthesis.