Sleep pathophysiology in posttraumatic stress disorder and idiopathic nightmare sufferers
Sleep pathophysiology in posttraumatic stress disorder and idiopathic nightmare sufferers
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DOI：
10.1016/s0006-3223(03)00071-4
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发表时间：
2003-11-15
影响因子：
10.6
通讯作者：
Nielsen, TA
中科院分区：
文献类型：
--
作者：
Germain, A;Nielsen, TA
背景：夜惊在创伤后应激障碍（PTSD）中很常见，但也经常以特发性形式发生。在这两组中与睡眠障碍相关的发现是不一致的，并且特发性噩梦很少。本研究的目的是探讨是否睡眠异常PTSD患者与频繁的噩梦（P-NM）不同，观察在非PTSD，特发性噩梦（I-NM）患者和健康individuals.Methods：睡眠措施，从9 P-NM患者，11 I-NM患者，和13名健康对照组。所有参与者睡在实验室连续两个晚上，脑电图，眼电图，下巴和腿肌电图，心电图，呼吸recordedcontinuous.Results：创伤后噩梦患者有显着更多的夜间觉醒比I-NM患者和对照组。P-NM和I-NM患者在快速眼动（REM）和非REM睡眠期间周期性腿部运动（PLM）指数升高。结论：创伤后噩梦患者比I-NM患者和对照组表现出更多的夜间觉醒，这支持了创伤后应激障碍患者睡眠中过度觉醒的假设;然而，P-NM和I-NM患者中PLM指数升高表明PLM可能不是PTSD患者睡眠中过度觉醒的标志。相反，PLM可能是导致强烈消极梦想的过程的相关因素。生物精神病学2003;54：1092-1098（C）2003生物精神病学学会
Background: Nightmares are common in posttraumatic stress disorder (PTSD), but they also frequently occur in idiopathic form. Findings associated with sleep disturbances in these two groups have been inconsistent, and sparse for idiopathic nightmares. The aim of the present study was to investigate whether sleep anomalies in PTSD sufferers with frequent nightmares (P-NM) differ from those observed in non-PTSD, idiopathic nightmare (I-NM) sufferers and healthy individuals.Methods: Sleep measures were obtained from nine P-NM sufferers, 11 I-NM sufferers, and 13 healthy control subjects. All participants slept in the laboratory for two consecutive nights where electroencephalogram, electro-oculogram, chin and leg electromyogram, electrocardiogram, and respiration were recorded continuously.Results: Posttraumatic nightmare sufferers had significantly more nocturnal awakenings than did I-NM sufferers and control subjects. Elevated indices of periodic leg movements (PLMs) during rapid eye movement (REM) and non-REM sleep characterized both P-NM and I-NM sufferers.Conclusions: Posttraumatic nightmare sufferers exhibit more nocturnal awakenings than do I-NM sufferers and control subjects, which supports the hypothesis of hyperarousal in sleep in PTSD sufferers; however, elevated PLM indices in both P-NM and I-NM sufferers suggest that PLMs may not be a marker of hyperarousal in sleep of PTSD sufferers. Rather, PLMs may be a correlate of processes contributing to intense negative dreaming. Biol Psychiatry 2003;54:1092-1098 (C) 2003 Society of Biological Psychiatry