Germline immunoglobulin genes: disease susceptibility genes hidden in plain sight?
Germline immunoglobulin genes: disease susceptibility genes hidden in plain sight?
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DOI：
10.1016/j.coisb.2020.10.011
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发表时间：
2020-12
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
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尽管免疫球蛋白基因对免疫功能有着重要的作用，但很少被认为是疾病易感基因。这似乎是一个后果的历史观点抗体库的形成，不再站，和困难，直到最近围绕文件的套件抗体基因在任何个人。如果这些重要的基因是可访问的GWAS研究中，等位基因的变化在人群中需要更好地记录，并策划一套与抗体基因相关的基因组变异需要制定。2019冠状病毒病大流行引起的病例研究提供了满足这些需求的机会，并可能深入了解这种感染结果的深刻变化。
Immunoglobulin genes are rarely considered as disease susceptibility genes despite their obvious and central contributions to immune function. This appears to be a consequence of historical views on antibody repertoire formation that no longer stand, and of difficulties that until recently surrounded the documentation of the suite of antibody genes in any individual. If these important genes are to be accessible to GWAS studies, allelic variation within the human population needs to be better documented, and a curated set of genomic variations associated with antibody genes needs to be formulated. Repertoire studies arising from the COVID-19 pandemic provide an opportunity to meet these needs, and may provide insights into the profound variability that is seen in outcomes to this infection.