Natural saline-flush is sufficient to maintain patency of immobilized-urokinase double-lumen catheter used to provide temporary blood access for hemodialysis
Natural saline-flush is sufficient to maintain patency of immobilized-urokinase double-lumen catheter used to provide temporary blood access for hemodialysis
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DOI：
10.1159/000081811
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发表时间：
2004-01-01
影响因子：
3
通讯作者：
Suzuki, M
中科院分区：
文献类型：
--
作者：
Kaneko, Y;Iwano, M;Suzuki, M
背景资料：血栓闭塞是血液透析治疗中用于提供临时血液通路的中心静脉导管的常见并发症。肝素封管通常用于维持导管的通畅性，但肝素封管的必要性尚未确定。研究方法：将固定化尿激酶双腔中心静脉导管插入48例日本血液透析患者后，随机分配至肝素组的22例患者接受20 ml生理盐水冲洗，随后接受2 ml 1，000 U/ml肝素封管，随机分配至生理盐水组的26例患者仅接受20 ml生理盐水冲洗，每个管腔每天一次。结果：肝素组22例患者中仅1例观察到血栓闭塞，生理盐水组26例患者中仅1例观察到血栓闭塞。两组之间未观察到导管存活率的显著差异（p = 0.8599）。结论：自然生理盐水冲洗足以维持固定化尿激酶双腔中心静脉导管的通畅。版权所有（C）2004 S. Karger AG，巴塞尔。
Background: Thrombotic occlusion is a frequent complication of central venous catheters used to provide temporary blood access on hemodialysis therapy. Heparin-lock is conventionally used to maintain patency of the catheter, but the necessity of heparin-lock has not been determined yet. Methods: After the immobilized-urokinase double-lumen central venous catheter was inserted into 48 Japanese hemodialysis patients, 22 patients randomized to the heparin group received a 20-ml saline-flush, followed by 2 ml of 1,000 U/ml heparin-lock, and 26 patients randomized to the saline group received only the 20-ml saline-flush once a day for each lumen. Results: Thrombotic occlusion was observed in only 1 out of 22 patients in the heparin group and 1 out of 26 patients in the saline group. No significant difference of the catheter survival was observed between the two groups (p = 0.8599). Conclusions: Natural saline-flush is sufficient for maintaining the patency of an immobilized-urokinase double-lumen central venous catheter. Copyright (C) 2004 S. Karger AG, Basel.