Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy.
Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy.
复制标题
用于靶向光热化疗癌症治疗的仿生黑磷纳米片药物输送系统
DOI：
10.3389/fbioe.2021.707208
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发表时间：
2021
影响因子：
5.7
通讯作者：
Liu G
中科院分区：
文献类型：
--
作者：
Cao J;Qi J;Lin X;Xiong Y;He F;Deng W;Liu G
黑磷作为一种可生物降解的材料，被认为是一种有效的癌症光热治疗剂。然而，它的全身递送面临几个障碍，包括血液循环中的快速降解，免疫系统的快速清除，以及对肿瘤部位的递送充分性低。在这里，我们开发了一个仿生纳米颗粒平台，用于体内肿瘤靶向递送BP纳米片（BP NSs）。通过仿生策略，利用BP NSs与奥沙利铂（1,2-二氨基环己烷）铂（II） （DACHPt）络合物的活性物质配合，并进一步用间充质干细胞（MSC）衍生膜伪装纳米颗粒。我们通过光热效应和化学毒性的结合发现，DACHPt的掺入不仅减缓了BP的降解，而且增强了抗肿瘤作用。此外，MSC膜涂层提高了BP/DACHPt的稳定性、分散性和肿瘤靶向性，显著提高了其抗肿瘤效果。总之，我们的工作不仅为BP NSs的体内肿瘤靶向递送提供了新的策略，而且通过光热联合化疗获得了增强的抗肿瘤效果。
As a biodegradable material, black phosphorus (BP) has been considered as an efficient agent for cancer photothermal therapy. However, its systemic delivery faces several hurdles, including rapid degradation in blood circulation, quick clearance by the immune system, and low delivery sufficiency to the tumor site. Here, we developed a biomimetic nanoparticle platform for in vivo tumor-targeted delivery of BP nanosheets (BP NSs). Through a biomimetic strategy, BP NSs were utilized to coordinate with the active species of oxaliplatin (1,2-diaminocyclohexane) platinum (II) (DACHPt) complexions, and the nanoparticles were further camouflaged with mesenchymal stem cell (MSC)–derived membranes. We showed that the incorporation of DACHPt not only decelerated the BP degradation but also enhanced the antitumor effect by combining the photothermal effect with chemotoxicity. Furthermore, MSC membrane coating increased the stability, dispersibility, and tumor-targeting properties of BP/DACHPt, significantly improving the antitumor efficacy. In short, our work not only provided a new strategy for in vivo tumor-targeted delivery of BP NSs but also obtained an enhanced antitumor effect by combining photothermal therapy with chemotherapy.