pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms.
pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms.
复制标题
用于口服药物递送的 pH 响应载体：当前平台的挑战和机遇
DOI：
10.1080/10717544.2017.1279238
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发表时间：
2017-11
期刊：
影响因子：
6
通讯作者：
Gao J
中科院分区：
文献类型：
--
作者：
Liu L;Yao W;Rao Y;Lu X;Gao J
摘要口服给药因其给药方便、患者依从性好，尤其是对需要频繁给药的慢性疾病，是一种理想的胃肠外给药替代方案。口服给药是一个充满活力的研究领域，尽管有许多挑战限制了它们的有效递送，如酶降解，水解和胃肠道（GI）中肠上皮细胞的低渗透性。pH响应型载体由于能提高药物在胃中的稳定性和在肠道中的控释，因此具有良好的口服治疗系统的潜力。本文综述了以有机聚合物或无机材料为主要原料制备的pH响应型口服给药系统的研究现状，包括克服胃肠道屏障的策略、发展中面临的挑战和前景，重点介绍了提高口服给药生物利用度的技术趋势、pH响应型口服制剂的释药机制、pH响应型口服制剂的生物利用度和pH响应型口服制剂的生物利用度等方面的研究进展。以及它们在药物递送，例如蛋白质和肽治疗剂、疫苗接种、炎性肠病（IBD）和细菌感染中的应用。
Abstract Oral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal epithelium in the gastrointestinal (GI) tract. pH-Responsive carriers offer excellent potential as oral therapeutic systems due to enhancing the stability of drug delivery in stomach and achieving controlled release in intestines. This review provides a wide perspective on current status of pH-responsive oral drug delivery systems prepared mainly with organic polymers or inorganic materials, including the strategies used to overcome GI barriers, the challenges in their development and future prospects, with focus on technology trends to improve the bioavailability of orally delivered drugs, the mechanisms of drug release from pH-responsive oral formulations, and their application for drug delivery, such as protein and peptide therapeutics, vaccination, inflammatory bowel disease (IBD) and bacterial infections.
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