Effects of growth hormone administration for 6 months on bone turnover and bone marrow fat in obese premenopausal women
Effects of growth hormone administration for 6 months on bone turnover and bone marrow fat in obese premenopausal women
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DOI：
10.1016/j.bone.2014.01.022
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发表时间：
2014-05-01
期刊：
影响因子：
4.1
通讯作者：
Miller, Karen K.
中科院分区：
文献类型：
--
作者：
Bredella, Miriam A.;Gerweck, Anu V.;Miller, Karen K.
目的：腹部肥胖与低骨密度和生长激素（GH）分泌减少有关，生长激素是骨稳态的重要调节因子。我们研究的目的是确定短期生长激素对绝经前腹部肥胖妇女骨转换和骨髓脂肪标志物的影响。材料和方法：在一项为期6个月的随机、双盲、安慰剂对照试验中，我们研究了79名腹部肥胖的绝经前妇女（21-45岁），她们每天接受生长激素注射与安慰剂对照。主要观察指标为DXA和CT的体成分，质子磁共振成像的骨髓脂肪，P1NP， CTX, 25(OH)D, hsCRP，低羧化骨钙素（ucOC），前脂肪细胞因子1 (Pref 1)，载脂蛋白B （ApoB）和IGF-1。结果：与安慰剂相比，生长激素增加了IGF-1、P1NP、25(OH)D、ucOC、骨髓脂肪和瘦质量，降低了腹部脂肪、hsCRP和ApoB （p < 0.05）。CTX和Pref-1有升高的趋势。在所有参与者中，6个月IGF-1的增加与6个月P1NP的增加相关（p = 0.0005），这表明IGF-1增加最多的受试者骨形成的增加最多。6个月腹部脂肪、hsCRP和ApoB的下降与P1NP的6个月变化呈负相关，6个月瘦质量和25(OH)D的增加与P1NP的6个月变化呈正相关
Purpose: Abdominal adiposity is associated with low BMD and decreased growth hormone (GH) secretion, an important regulator of bone homeostasis. The purpose of our study was to determine the effects of a short course of GH on markers of bone turnover and bone marrow fat in premenopausal women with abdominal adiposity.Materials and methods: In a 6-month, randomized, double-blind, placebo-controlled trial we studied 79 abdominally obese premenopausal women (21-45y) who underwent daily sc injections of GH vs. placebo. Main outcome measures were body composition by DXA and CT, bone marrow fat by proton MR spectroscopy, P1NP, CTX, 25(OH)D, hsCRP, undercarboxylated osteocalcin (ucOC), preadipocyte factor 1 (Pref 1), apolipoprotein B (ApoB), and IGF-1.Results: GH increased IGF-1, P1NP, 25(OH)D, ucOC, bone marrow fat and lean mass, and decreased abdominal fat, hsCRP, and ApoB compared with placebo (p < 0.05). There was a trend toward an increase in CTX and Pref-1. Among all participants, a 6-month increase in IGF-1 correlated with 6-month increase in P1NP (p = 0.0005), suggesting that subjects with the greatest increases in IGF-1 experienced the greatest increases in bone formation. A six-month decrease in abdominal fat, hsCRP, and ApoB inversely predicted 6-month change in P1NP, and 6-month increase in lean mass and 25(OH)D positively predicted 6-month change in P1NP (p