FOXP3 and GARP (LRRC32): the master and its minion.

FOXP3 and GARP (LRRC32): the master and its minion.
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DOI:
10.1186/1745-6150-5-8
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发表时间:
2010-02-05
期刊:
影响因子:
5.5
通讯作者:
Buer J
Buer J
中科院分区:
生物学2区
文献类型:
--
作者:
Probst-Kepper M;Buer J

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转录因子FOXP3对CD4+CD25hiFOXP3+调节性T (Treg)细胞的发育和功能至关重要,但也在未获得调节性表型的活化人类辅助性T细胞中表达。这篇评论的重点是糖蛋白- a重复显性(GARP或LRRC32)最近被鉴定为活化的人类Treg细胞的特异性标记,它可能为更好的调节表型的分子定义提供缺失的一环。审稿人:Jim Di Danto博士、Benedita Rocha博士和Werner Solbach博士。
The transcription factor FOXP3 is essential for the development and function of CD4+CD25hiFOXP3+ regulatory T (Treg) cells, but also expressed in activated human helper T cells without acquisition of a regulatory phenotype. This comment focuses on glycoprotein-A repetitions predominant (GARP or LRRC32) recently identified as specific marker of activated human Treg cells, which may provide the missing link toward a better molecular definition of the regulatory phenotype. Reviewers: Dr Jim Di Danto, Dr Benedita Rocha and Dr Werner Solbach.
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