Enhanced production of nitric oxide in aortae from spontaneously hypertensive rats by interleukin-1 beta.
Enhanced production of nitric oxide in aortae from spontaneously hypertensive rats by interleukin-1 beta.
复制标题
IL-1β 增强自发性高血压大鼠主动脉中一氧化氮的产生。
DOI：
10.1093/ajh/6.7.602
复制
发表时间：
1993
影响因子：
3.2
通讯作者：
Vanhoutte,PM
中科院分区：
文献类型：
--
作者：
Junquero,DC;Schini,VB;Scott-Burden,T;Vanhoutte,PM
This study aimed to assess the left ventricular diastolic function of borderline hypertensive patients (BHT) and to determine the effect of long-term blood pressure control by an angiotensin converting enzyme inhibitor on the left ventricular filling profile. Pulsed Doppler echocardiograms were obtained from 18 BHT (14 men, 4 women; mean age: 55 years) and 20 age-sex matched normotensive controls. Studies were done at rest and immediately after exercise on a supine ergometer bicycle. Of the 18 patients, 11 were treated with delapril (30 mg/ day) and followed up with longitudinal studies for 24 weeks. At baseline, BHT had a normal left ventricular structure. They showed a decreased peak velocity of early filling (E) (43 ± 7 ν 56 ± 13 cm/sec, Ρ < .01) and E /A ratio (0.83 ± 0.2 ν 1.08 ± 0.3, Ρ < .01), whereas peak velocity of late filling (A) and deceleration time (Dec T) were similar in the two groups. Exercise-enhanced filling indices were observed in both groups. Following blood pressure control, no change was observed in the left ventricular morphology. In contrast, progressive improvement of resting and after exercise peak velocity of early filling and E /A ratio were achieved. This indicates that long-term angiotensin converting enzyme inhibition ameliorates cardiac function in borderline hypertension. Am J Hypertens 1993;6:547-553
