Tunable Upper Critical Solution Temperatures for Acrylamide Copolymers with Bile Acid Pendants.
Tunable Upper Critical Solution Temperatures for Acrylamide Copolymers with Bile Acid Pendants.
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DOI：
10.1021/acs.biomac.7b00860
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发表时间：
2017-07
影响因子：
6.2
通讯作者：
Yongguang Jia;Q. Yu;Zhiyuan Ma;Meng Zhang;X. X. Zhu-X.
中科院分区：
文献类型：
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作者：
Yongguang Jia;Q. Yu;Zhiyuan Ma;Meng Zhang;X. X. Zhu-X.
以胆汁酸的丙烯酰胺衍生物为疏水共聚单体，通过可逆加成和断裂链转移(RAFT)聚合，合成了一系列P(AAm-co-CAA)共聚物。这些共聚物在加热到与上临界溶液温度(UCST)相关的混合温度(TMix)时，在水中表现出急剧和可逆的不溶转变。这些共聚物的混合物可以方便地调节到实际温度范围，约37°C，用于生物医学应用。TMix随胆汁酸型丙烯酰胺摩尔分数的增加和共聚物水溶液浓度的增加而增大。天然宿主分子β-环糊精的加入降低了TMix。动态光散射和透射电子显微镜也证明了共聚物的不溶性转变。胆汁酸和β-环糊精的生物相容性可能使这些共聚物在生物医学应用中具有潜在的应用价值。
Acrylamide derivatives of bile acids are chosen as a hydrophobic comonomer to copolymerize with acrylamide via reversible addition and fragmentation chain transfer (RAFT) polymerization to afford a series of copolymers of P(AAm-co-CAA). These copolymers exhibit a sharp and reversible insoluble-soluble transition in water upon heating to a mixing temperature (Tmix) related to the upper critical solution temperature (UCST). Tmix of these copolymers can be conveniently tuned to a practical temperature range, around 37 °C for biomedical applications. Tmix rises with increasing molar fraction of the bile acid-based acrylamide and increasing concentration of the aqueous solution of the copolymers. The addition of a natural host molecule β-cyclodextrin lowered the Tmix. The insoluble-soluble transition of the copolymers was also evidenced by dynamic light scattering and transmission electron microscopy. The biocompatible nature of the bile acids and β-cyclodextrins may make these copolymers potentially useful for biomedical applications.