The case definition of chronic fatigue syndrome.

The case definition of chronic fatigue syndrome.
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慢性疲劳综合症的病例定义。

DOI:
10.1023/a:1014248301721
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发表时间:
2002
影响因子:
9.1
通讯作者:
Gupta,Sudhir
Gupta,Sudhir
中科院分区:
医学2区
文献类型:
--
作者:
Tan,EngM;Sugiura,Kazumitsu;Gupta,Sudhir

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1994年的慢性疲劳综合征病例定义不仅被广泛用于诊断,而且还用于该临床实体的临床和实验室观察。1994年病例定义的标准主要是基于症状,而不是基于体征或化学或免疫学测试。这种情况导致临床和实验室观察结果相互矛盾,很可能是由于在不同中心研究的患者人群不同。根据最近的一些出版物,这种疾病实体似乎出现了一种新的图像,我们建议可以将慢性疲劳综合征分为四个不同的亚类。这些亚类包括慢性疲劳伴主要神经系统疾病(如记忆力或注意力受损和头痛)、慢性疲劳伴主要内分泌系统疾病(如睡眠不佳和运动后不适)、慢性疲劳伴肌肉骨骼系统疾病(如肌肉疼痛和关节疼痛)和慢性疲劳伴免疫系统/感染性疾病(如咽喉痛和淋巴结压痛)。这表明,如果临床和实验室为基础的研究慢性疲劳综合征进行更同质的亚组的患者,从一个中心到另一个中心的数据可能不会冲突,更多的见解可以摆脱这种临床条件的性质。
The 1994 case definition of chronic fatigue syndrome is widely used not only for diagnosis but also for clinical and laboratory-based observations of this clinical entity. The criteria for the 1994 case definition are based primarily on symptoms and not on physical signs or chemical or immunological tests. This situation has resulted in conflicting clinical and laboratory observations that in all likelihood is due to different populations of patients being studied in different centers. Based on some of the recent publications, there appears to be an emerging picture of this disease entity that we propose could be used to subgroup chronic fatigue syndrome into four different subclasses. These subclasses would consist of chronic fatigue with primarily nervous system disorders such as impaired memory or concentration and headache, chronic fatigue with primarily endocrine system disorders such as unrefreshing sleep and postexertional malaise, chronic fatigue with musculoskeletal system disorders such as muscle pain and joint pain, and chronic fatigue with immune system/infectious disorders such as sore throat and tender lymph nodes. It is suggested that if clinical and laboratory-based studies on chronic fatigue syndrome were conducted on more homogeneous subgroups of patients, the data from one center to the other might not be as conflicting and more insights can be shed on the nature of this clinical condition.
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