Free cortisol levels after awakening: A reliable biological marker for the assessment of adrenocortical activity
Free cortisol levels after awakening: A reliable biological marker for the assessment of adrenocortical activity
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DOI：
10.1016/s0024-3205(97)01008-4
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发表时间：
1997-11-21
期刊：
影响因子：
6.1
通讯作者：
Kirschbaum, C
中科院分区：
文献类型：
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作者：
Pruessner, JC;Wolf, OT;Kirschbaum, C
在三项独立研究中，对儿童、成人和老年受试者(总计152人)早晨醒来后的游离皮质醇水平进行了重复测量。皮质醇是通过每隔10分钟或15分钟采集唾液样本30-60分钟来评估的，分别从醒来时开始两天(研究1和2)或一天(研究3)。在所有三项研究中，无论男女，在醒来后的前30分钟内，所有日子的游离皮质醇水平都上升了50%-75%。与男性相比，绝经前的女性在所有的日子里都表现出更强的增长，醒来后的峰值延迟。在研究2中，服用口服避孕药的妇女清晨游离皮质醇水平有降低的趋势(p=.10)。三天(研究1和研究2)或两天(研究3)清晨游离皮质醇水平的曲线下面积(AUC)的稳定性介于r=0.39和r=0.67(p
In three independent studies, free cortisol levels after morning awakening were repeatedly measured in children, adults and elderly subjects (total n=152). Cortisol was assessed by sampling saliva at 10 or 15 minute intervals for 30-60 minutes, beginning at the time of awakening for two days (Study 1 and 2) or one (Study 3) day, respectively. In all three studies, free cortisol levels increased by 50-75% within the first 30 minutes after awakening in both sexes on all days. Premenopausal women consistently showed a stronger increase with a delayed peak after awakening compared to men on all days. In Study 2, there was a tendency for lower early morning free cortisol levels for women taking oral contraceptives (p=.10). Stability of the area under the curve (AUC) of the early morning free cortisol levels over the three (Study 1 and 2) or two (Study 3) days ranged between r=.39 and r=.67 (p